DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment en and EN2

DIOPT Version :9

Sequence 1:	NP_523700.2	Gene:	en / 36240	FlyBaseID:	FBgn0000577	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001418.2	Gene:	EN2 / 2020	HGNCID:	3343	Length:	333	Species:	Homo sapiens

Alignment Length:	238	Identity:	106/238 - (44%)
Similarity:	129/238 - (54%)	Gaps:	62/238 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 CSSAASSLNSSPSSRLGASGS----GVNAS-------SPQPQPIPP---------PSAVSRDSG- 398
            |:.|............||||:    |...|       |.:|:..||         |:|.|...|
Human    89 CAGAGGGRGGGAGGEGGASGAEGGGGAGGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGD 153

  Fly   399 --------------------------------------MESSDDTRSETGSTTTEGGKNEMWPAW 425
                                                  ..|||...|:.|:..  |.:..:||||
Human   154 GEGGSKTLSLHGGAKKGGDPGGPLDGSLKARGLGGGDLSVSSDSDSSQAGANL--GAQPMLWPAW 216

  Fly   426 VYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSE 490
            |||||||||||||||.|:||: |:...::|||||||::|||.|||.||..||||||:|||.|:.|
Human   217 VYCTRYSDRPSSGPRSRKPKK-KNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQE 280

  Fly   491 LGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTT 533
            |.|||:|||||||||||||||:||:||.||:.|||||||||:|
Human   281 LSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHST 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeobox	457..510	CDD:278475	40/52 (77%)
en	NP_523700.2	Engrail_1_C_sig	512..541	CDD:287495	16/22 (73%)
EN2	NP_001418.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..206		19/110 (17%)
		homeobox domain	243..302		44/58 (76%)
		Homeobox	247..300	CDD:306543	40/52 (77%)
		Engrail_1_C_sig	302..331	CDD:313702	16/22 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7480
eggNOG	1	0.900	-	-		E1_KOG0493
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm8573
orthoMCL	1	0.900	-	-		OOG6_106342
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2569
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800