DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment en and En2

DIOPT Version :9

Sequence 1:	NP_523700.2	Gene:	en / 36240	FlyBaseID:	FBgn0000577	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_034264.1	Gene:	En2 / 13799	MGIID:	95390	Length:	324	Species:	Mus musculus

Alignment Length:	232	Identity:	103/232 - (44%)
Similarity:	130/232 - (56%)	Gaps:	54/232 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 SGCSSAASSLNSSPSSRLGASGSG-----VNASSPQPQPIPPPS------------AVSRDSGME 400
            :|...|......:.::..|..|:|     :.|...:|.|...||            ||..:.|.:
Mouse    86 AGAGGARGGEGGAGTTEGGGGGAGGAEQLLGARESRPNPACAPSAGGTLSAAAGDPAVDGEGGSK 150

  Fly   401 ----------------------------------SSDDTRSETGSTTTEGGKNEMWPAWVYCTRY 431
                                              |||...|:..:|.  |.:..:||||||||||
Mouse   151 TLSLHGGAKKPGDPGGSLDGVLKARGLGGGDLSVSSDSDSSQASATL--GAQPMLWPAWVYCTRY 213

  Fly   432 SDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEA 496
            |||||||||.|:||: |:...::|||||||::|||.|||.||..||||||:|||.|:.||.|||:
Mouse   214 SDRPSSGPRSRKPKK-KNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNES 277

  Fly   497 QIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTT 533
            |||||||||||||||:||:||.||:.|||||||||:|
Mouse   278 QIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHST 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeobox	457..510	CDD:278475	40/52 (77%)
en	NP_523700.2	Engrail_1_C_sig	512..541	CDD:287495	16/22 (73%)
En2	NP_034264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..174		12/84 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..240		15/25 (60%)
		Homeobox	238..291	CDD:278475	40/52 (77%)
		Engrail_1_C_sig	293..322	CDD:287495	16/22 (73%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7450
eggNOG	1	0.900	-	-		E1_KOG0493
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm8801
orthoMCL	1	0.900	-	-		OOG6_106342
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2569
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.800