DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment en and En1

DIOPT Version :9

Sequence 1:	NP_523700.2	Gene:	en / 36240	FlyBaseID:	FBgn0000577	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_034263.2	Gene:	En1 / 13798	MGIID:	95389	Length:	401	Species:	Mus musculus

Alignment Length:	496	Identity:	164/496 - (33%)
Similarity:	214/496 - (43%)	Gaps:	143/496 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 AAAAAAAHAHAAALQQRLSGSGSPASCSTPASSTPLTIKEEESDSVIGDMSFHNQTHTTNEEEEA 139
            |.||||....:.:|....|||......|.|.|..|.. ....:...:..::.|
Mouse    18 AVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAP-PSPPAAPCLPPLAHH------------ 69

  Fly   140 EEDDDIDVDVDDTSAGGRLPP------------------PAHQQQSTAK--PSLAFSISNILSDR 184
                            ..|||                  ||||.|..|:  .:..|.|.|||...
Mouse    70 ----------------PHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPD 118

  Fly   185 FGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANFL 249
            ||                     .:.:...|      .||..|    |||....||
Mouse   119 FG---------------------CKKEQPLP------QLLVAS----AAAGGGAAA--------- 143

  Fly   250 NCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTM 314
                 ....|:..:..|:...|.        |:.|..:.|:   .|...||...:..|.|..
Mouse   144 -----GGGSRVERDRGQTGAGRD--------PVHSLGTRAS---GAASLLCAPDANCGPPDG--- 189

  Fly   315 TQP--PLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGV 377
            :||  .:|:.||...:|..|:.|:..::.::||            ||::..|.||...|  |||.
Mouse   190 SQPATAVSAGASKAGNPAAAAAAAAAAAAAAVA------------AAAAAASKPSDSGG--GSGG 240

  Fly   378 NASSPQPQ----PIPPPSAV---SRDSGMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRP 435
            ||.||..|    |...|:.:   |.:.|.....|::...           :||||||||||||||
Mouse   241 NAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPL-----------VWPAWVYCTRYSDRP 294

  Fly   436 SSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKI 500
            |||||.|:.|:.|::..| |||||||::|||.|||.||..|||:||:|||.|:.||.|||:||||
Mouse   295 SSGPRTRKLKKKKNEKED-KRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKI 358

  Fly   501 WFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEE 541
            |||||||||||:||.||.|||.|||||||||:|..:..::|
Mouse   359 WFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDE 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeobox	457..510	CDD:278475	39/52 (75%)
en	NP_523700.2	Engrail_1_C_sig	512..541	CDD:287495	17/28 (61%)
En1	NP_034263.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		22/112 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..167		7/50 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..253		12/25 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..315		12/22 (55%)
		Homeobox	315..368	CDD:278475	39/52 (75%)
		Engrail_1_C_sig	370..399	CDD:287495	17/28 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834693
Domainoid	1	1.000	94	1.000	Domainoid score	I7450
eggNOG	1	0.900	-	-		E1_KOG0493
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm8801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2569
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.830