Protein Alignment en and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_446103.2
• Gene: Nkx2-5 / 114109
• RGDID: 620520
• Length: 319
• Species: Rattus norvegicus
• Alignment Length: 309
• Identity: 73/309 - (23%)
• Similarity: 107/309 - (34%)
• Gaps: 123/309 - (39%)

  Fly   208 SRSQTATPSAFTRVDLLEFSRQQQAAAA----AATAAMMLERANFLNCFNPAAYPRIHEEIVQSR 268
            |.:.|.||  |:..|:|...:||::.||    |...|.:...:..|..|.|.||
  Rat     4 SPALTHTP--FSVKDILNLEQQQRSLAAGDLSARLEATLAPASCMLAAFKPEAY----------- 55

  Fly   269 LRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPAS 333
                                :.||.:|.| |.:..:::| ||                .|||.
  Rat    56 --------------------SGPEAAAPG-LAELRAELG-PA----------------PSPPK-- 80

  Fly   334 NASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGVNASSPQPQPIPPPSAVSRD-S 397
                                 ||.|   ..::|:....|.|        .|.|...|.|..:: .
  Rat    81 ---------------------CSPA---FPTAPTFYPRAYG--------DPDPAKDPRADKKELC 113

  Fly   398 GMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFS 462
            .::.:    .|.....|:|.:.                   ||.||          .::||..||
  Rat   114 ALQKA----VELDKAETDGAER-------------------PRARR----------RRKPRVLFS 145

  Fly   463 SEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKK 511
            ..|:..|:|.|.:.|||:...|.||:|.|.|...|:||||||:|.|.|:
  Rat   146 QAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKR 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeodomain	455..511	CDD:459649	26/55 (47%)
		Engrail_1_C_sig	512..542	CDD:431338	73/309 (24%)
Nkx2-5	NP_446103.2	Homeodomain	144..194	CDD:459649	24/49 (49%)