Protein Alignment INHBA and mav

DIOPT Version :10

• Sequence 1: XP_054214132.1
• Gene: INHBA / 3624
• HGNCID: 6066
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 117/600 - (19%)
• Similarity: 205/600 - (34%)
• Gaps: 171/600 - (28%)

Human    75 ENLLKRR--------RKKKTPKKKIKKSTHT-KKPAREGGGKAGPFK-KAITTTFAARMPLLWLR 129
            ||..||.        |.|.|||..:|....: .|.:|:....|...| ..|..:.:...|.|:.:
  Fly   147 ENEAKRLETNQHPIIRAKSTPKMGLKNVFESFSKQSRDSIYNASSNKYSLINVSQSKNFPQLFNK 211

Human   130 GFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDV-----PNSQP--EMVEAVKKH-ILN 186
              .|:..||  .:.|....:....             :|:     .:|:|  .:.|...|| :|.
  Fly   212 --KLSVQWI--NTVPIQSRQTRET-------------RDIGLETKRHSKPSKRVDETRLKHLVLK 259

Human   187 MLHLKKRPD-----VTQPVPKAALLNAI-----------------------RKLHVGKVGENGYV 223
            .|.:||.||     ::|....:..:..:                       |.||...:..||:.
  Fly   260 GLGIKKLPDMRKVNISQAEYSSKYIEYLSRLRSNQEKGNSYFNNFMGASFTRDLHFLSITTNGFN 324

Human   224 EIEDDIGR---------RAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSV----VERA 275
            :|.:...|         |...|....|....:...|..|....|||.:: ...|.:.    ::.|
  Fly   325 DISNKRLRHRRSLKKINRLNQNPKKHQNYGDLLRGEQDTMNILLHFPLT-NAQDANFHHDKIDEA 388

Human   276 EVWLFLKVPKANRT---------RTKVT----------------IRLFQQQKHPQGSLDTGEEAE 315
            .|.|.|....:..|         :.|::                :.|.|..|:         .::
  Fly   389 NVRLMLLYSSSLATNFRRGPGSRKNKISQISGNDNIERHCNFGDVNLNQSNKN---------SSQ 444

Human   316 EVGLK------GERSELLLSEKV------VDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQ 368
            ::.||      ..|...:.|.|:      ....::.|..|.|:.:::..|::...:|.:.|.|::
  Fly   445 QLTLKVYQLLSANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKSHENLGIEIQCDK 509

Human   369 CQESGASLV------LLGKKKKKEEE-----------GEGKKKGGGEGGAGADEEKEQSHRPFLM 416
            |:..||.::      ...:.....:|           |.|.......|.|...:....::|....
  Fly   510 CKSIGARILSDFSPSTPPRSTASSDEHLNLMPVLNIIGHGTLNSQQHGDADIHQIMLTNNRSDQY 574

Human   417 LQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIA 481
            :..|.:.|...|:.:....|......||:.|..|:||.|...::|:.|..:.|.||.|.||..
  Fly   575 VHHRSNHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVFDAGYCHGRCPPR-- 637

Human   482 GTSGSSLSFHSTVINHYRMRG--------HSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKK--- 535
                     |:...:|..::.        .:|    :.||.|:||..:.:|:.|:..:...|
  Fly   638 ---------HNPAHHHALLQSLIWQEDHKRAP----RPCCTPSKLEMLEILHVDENHSDKLKIST 689

Human   536 --DIQNMIVEECGCS 548
              |:|   |.||.||
  Fly   690 WSDMQ---VVECACS 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INHBA	XP_054214132.1	TGFb_propeptide	178..376	CDD:480997	50/276 (18%)
		TGF_beta_INHBA	441..548	CDD:381674	31/119 (26%)
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	16/88 (18%)
		TGF_beta_maverick	598..700	CDD:381633	31/119 (26%)