Protein Alignment inv and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 430
• Identity: 101/430 - (23%)
• Similarity: 135/430 - (31%)
• Gaps: 138/430 - (32%)

  Fly   146 PPSEGPPFSPEDLLQLPPSTGTFQEEFLRKSQLYAEELMKQQMHLMAAARVNALTAAAAGKQLQM 210
            ||..||...|     .||:...           .|.:.|..:..|....|......||:.
Mouse    17 PPPPGPGSGP-----APPAPAA-----------TARDTMDGRAELPIFPRAGVPPLAASD----- 60

  Fly   211 AMAAAAVATVPSGQDALAQLTATALGLGPGGAVHPHQQLLLQRDQVHHHHHMQNHLNNNENLHER 275
                 .|..||.|                .||..|...                         .|
Mouse    61 -----TVPAVPEG----------------AGAARPAAP-------------------------PR 79

  Fly   276 ALKFSIDNILKAD-FGSRLPK----------------------IGALSGNIGGGSVS----GSST 313
            ...||:.:||..: |.||..:                      :.|.||......:.    .::|
Mouse    80 PTSFSVLDILDPNKFNSRRRRCVLLGPVVPATCAPCAPAACVAVPAASGRSPRAELERRALSAAT 144

  Fly   314 GSSKNSGNTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTT 378
            |.:..:|         ..|..:|......::.|...||.|..|..|       ||...|......
Mouse   145 GVAAAAG---------AEPTSAGDSYRADEAEANGYSSGSGRSPTA-------DSEDEAPEDEDE 193

  Fly   379 NTSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKP 443
            ..:....|...:..|..|:|..||.|     ||.|  ..|.|..:...|..:.|  ||...|..|
Mouse   194 EEAPEVQDAQGTEEPRGGSGGLGARG-----SGCP--GAAEVEASPVDDTAAPG--PRGNSPGAP 249

  Fly   444 ATSSSAAGGGGGGVEKGEAA-------------DGGGVPEDKRPRTAFSGTQLARLKHEFNENRY 495
            ...::|.|.|..|.....||             ...|.|  :|.||||:..||..|:::|...||
Mouse   250 GPPATATGAGSAGSTPQGAAVTTKPKRKRTGSDSKSGKP--RRARTAFTYEQLVALENKFKATRY 312

  Fly   496 LTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNP 535
            |:...|..|:..|.|.|.|:||||||:|.|.||    :||
Mouse   313 LSVCERLNLALSLSLTETQVKIWFQNRRTKWKK----QNP 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	26/55 (47%)
		Engrail_1_C_sig	529..554	CDD:431338	2/7 (29%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		21/131 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		39/172 (23%)
		Homeodomain	289..345	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		5/11 (45%)