DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and hoxb3

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001015971.1	Gene:	hoxb3 / 548725	XenbaseID:	XB-GENE-482576	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	246	Identity:	74/246 - (30%)
Similarity:	105/246 - (42%)	Gaps:	44/246 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 GNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANI------CSNSNDSNS-------TATSS 375
            |...|.::...|....|..|.::.:..||..|..|...      |...|.|:.       ||..|
Frog    24 GYEGPQQSFPTSSHMDNEFQRSSCSLQSLGHSGPLVKAKNLNGSCMRPNLSSEQSQPLSPTANPS 88

  Fly   376 STTNTSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKP 440
            |.||:|.:...|.|..|..:.|..:.||.:         ::| |:..:|.:.:..|       .|
Frog    89 SNTNSSSSQASLSKPSPAKSQASGSPASKQ---------IFP-WMKESRQNSKQKS-------SP 136

  Fly   441 KKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLS 505
            ..||..|.    ||.....|.:|       .||.|||::..||..|:.||:.||||...||.:::
Frog   137 PAPAAESC----GGDRSPPGSSA-------SKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMA 190

  Fly   506 GELGLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTRE 556
            ..|.|:|.||||||||:|.|.||....|   .:...:.|....||.||:.:
Frog   191 NLLNLSERQIKIWFQNRRMKYKKDQKVK---GMSSSSGGASPTSTPPLSMQ 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	27/52 (52%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	5/24 (21%)
hoxb3	NP_001015971.1	Homeobox	160..212	CDD:306543	27/51 (53%)
hoxb3	NP_001015971.1	DUF4074	325..384	CDD:315871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910