DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and HOXB8

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_076921.1	Gene:	HOXB8 / 3218	HGNCID:	5119	Length:	243	Species:	Homo sapiens

Alignment Length:	179	Identity:	53/179 - (29%)
Similarity:	70/179 - (39%)	Gaps:	62/179 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 AGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEK 459
            |.|...|...:..|.|.:|.....|:       ||                 .:|||
Human   113 AAASGLGEEAEGSEQSPSPTQLFPWM-------RP-----------------QAAAG-------- 145

  Fly   460 GEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRA 524
                       .:|.|..:|..|...|:.||..|.|||.|||.::|..|||.|.|:||||||:|.
Human   146 -----------RRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRM 199

  Fly   525 KLKKSSGTKNPLALQLMAQGLYNHSTIPLTR-EEEEL--QELQEAASAA 570
            |.||.:                |....|.:: |:|||  |:|:.|..||
Human   200 KWKKEN----------------NKDKFPSSKCEQEELEKQKLERAPEAA 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	27/52 (52%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	2/24 (8%)
HOXB8	NP_076921.1	Antp-type hexapeptide	134..139		1/11 (9%)
		Homeobox	150..203	CDD:395001	27/52 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..243		12/46 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910