DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and HOXA2

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens

Alignment Length:	237	Identity:	67/237 - (28%)
Similarity:	102/237 - (43%)	Gaps:	32/237 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 SLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPP-----PAAGAGATGASGKSGEDSGTPIVW 416
            |||. |..|....:....||:..||......:..||     |:...|:....|..|....:|.
Human    17 SLAE-CLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGGRPKPSPA-- 78

  Fly   417 PAWVYCTRYSDRPSSGRSP------RARKPKK-----PATSSSAAGGGGGGV-----EKGEAADG 465
                 .:|.|..|:....|      :.:|..|     ||.:::|.....|..     |..|.|||
Human    79 -----GSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADG 138

  Fly   466 GGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKKSS 530
            .| ...:|.|||::.|||..|:.||:.|:||...||.:::..|.|.|.|:|:||||:|.|.|:.:
Human   139 SG-GGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQT 202

  Fly   531 GTKNPLALQLMAQGLYNHSTIPLTREEEELQELQEAASAAAA 572
            ..|.....:...:.|.:...:  ..:|||....::|.|.:.|
Human   203 QCKENQNSEGKCKSLEDSEKV--EEDEEEKTLFEQALSVSGA 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	25/52 (48%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	2/24 (8%)
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93		10/57 (18%)
		Antp-type hexapeptide	94..99		0/4 (0%)
		Homeobox	147..200	CDD:395001	25/52 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910