DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and hoxd3a

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_571200.1	Gene:	hoxd3a / 30349	ZFINID:	ZDB-GENE-990415-120	Length:	396	Species:	Danio rerio

Alignment Length:	277	Identity:	74/277 - (26%)
Similarity:	107/277 - (38%)	Gaps:	89/277 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 HERALKFSIDNILKADFGSRLPKIGALS---GNIGGGSVSGSSTGSSKNSGNTNGNRSPLKAPKK 334
            |:.....||:|    |:.|.:..|...|   .....|.::||....|.:.||:
Zfish    30 HQGFSSSSIEN----DYQSPICPIQTTSVRQATHKNGDINGSCMRPSASQGNS------------ 78

  Fly   335 SGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGA 399
              :|.::::...||..:.|         |.|..:|||...              |||
Zfish    79 --QPESISEQQQAAPLAAS---------SPSPSTNSTQKK--------------KSP-------- 110

  Fly   400 TGASGKSGEDSGTPI----VWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEKG 460
                ..:|..:.||:    ::| |:..||.:.:..|...|.|                      |
Zfish   111 ----SSNGSSTATPVISKQIFP-WMKETRQNAKQKSTNCPAA----------------------G 148

  Fly   461 EAADGGGV--PEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKR 523
            |..|....  |..||.|||::..||..|:.||:.||||...||.:::..|.|.|.||||||||:|
Zfish   149 ETCDDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRR 213

  Fly   524 AKLKKSSGTK----NPL 536
            .|.||...:|    :||
Zfish   214 MKYKKDQKSKGIMHSPL 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	27/52 (52%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	3/12 (25%)
hoxd3a	NP_571200.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..163		40/208 (19%)
		Abdominal-A	116..237	CDD:332641	47/138 (34%)
		Antp-type hexapeptide	126..131		2/5 (40%)
		Homeobox	165..217	CDD:306543	27/51 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..246		3/12 (25%)
		DUF4074	333..394	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910