DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and hoxa2b

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_571181.1	Gene:	hoxa2b / 30325	ZFINID:	ZDB-GENE-990415-98	Length:	363	Species:	Danio rerio

Alignment Length:	204	Identity:	58/204 - (28%)
Similarity:	91/204 - (44%)	Gaps:	40/204 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 NSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPP--------AAGAGATGASGK 405
            ||..|.:..|.:.....:...|::..|||.:.|    .|:  |||        ..|:....:..|
Zfish    13 NSQPSLAECLTSFPPVGDAFQSSSIKSSTLSHS----TLI--PPPFEQTIPSLNPGSHPRHSRPK 71

  Fly   406 SGEDSGTPIVWPAWVYCTRYSDRPSSGRSP------RARKPKKPATSSSAAGGGGGGV---EKG- 460
            ...:...|:              |::...|      ..:..||..|:|:||....|.:   .:|
Zfish    72 QNPNGSCPL--------------PAASLPPEYPWMKEKKASKKNQTTSTAATTDPGPLYFSPQGS 122

  Fly   461 -EAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRA 524
             |.:|||. ...:|.|||::.|||..|:.||:.|:||...||.:::..|.|.|.|:|:||||:|.
Zfish   123 PEISDGGS-GATRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRM 186

  Fly   525 KLKKSSGTK 533
            |.|:.:..|
Zfish   187 KHKRQTQCK 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	25/52 (48%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	1/5 (20%)
hoxa2b	NP_571181.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..132		22/110 (20%)
		Antp-type hexapeptide	88..93		0/4 (0%)
		Homeobox	137..189	CDD:278475	25/51 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..218		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910