DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and en2a

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_571119.2	Gene:	en2a / 30243	ZFINID:	ZDB-GENE-980526-167	Length:	265	Species:	Danio rerio

Alignment Length:	301	Identity:	123/301 - (40%)
Similarity:	154/301 - (51%)	Gaps:	82/301 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 NENLHERALKFSIDNILKADFG-SRLPKIGALSGNIG---GGSVSGSSTGS------SKNSGNTN 323
            |..|..|...|.|||||:.||| .:...|.....|.|   ..:.:|.|||.      ::.:..|:
Zfish    33 NLQLPHRITNFFIDNILRPDFGRKKEANITRYEDNHGARENHNPTGPSTGQVGSTVPAEEASTTH 97

  Fly   324 GNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLV 388
            .:....:|..:|.:||.....|             .:.|..|.      :.||.:|::|
Zfish    98 TSSGGKEAEIESEEPLKPRGEN-------------VDQCLGSE------SDSSQSNSNG------ 137

  Fly   389 KSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGG 453
                                .:|..::|||||||||||||||||  ||:|||||.|.|.
Zfish   138 --------------------QTGQGMLWPAWVYCTRYSDRPSSG--PRSRKPKKKAASK------ 174

  Fly   454 GGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIW 518
                            |||||||||:..||.|||.||..||||||:|||.|:.||||||:|||||
Zfish   175 ----------------EDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIW 223

  Fly   519 FQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEEE 559
            |||||||:||:||.||.||:.|||||||||||   |.:|::
Zfish   224 FQNKRAKIKKASGVKNGLAIHLMAQGLYNHST---TSKEDK 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	40/52 (77%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	17/24 (71%)
en2a	NP_571119.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..142		19/121 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..180		20/48 (42%)
		Homeobox	179..232	CDD:278475	40/52 (77%)
		Engrail_1_C_sig	234..263	CDD:287495	19/31 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm6346
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.010