DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and en2b

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_571115.1	Gene:	en2b / 30238	ZFINID:	ZDB-GENE-980526-40	Length:	261	Species:	Danio rerio

Alignment Length:	303	Identity:	119/303 - (39%)
Similarity:	152/303 - (50%)	Gaps:	96/303 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 LHERALKFSIDNILKADFGSRLPKIGALSGNI-------------GGGS---VSGSSTGSSKNSG 320
            |..|...|.|||||:.|||.|  |.|:....|             |.|.   |||..|.|.:
Zfish    35 LPHRITNFYIDNILRPDFGRR--KEGSRRDEINIVERENRCPSAPGSGQVAPVSGEGTSSPR--- 94

  Fly   321 NTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPV 385
                   .:.|.||         ::.:.:.||...:...:.|. |:||:
Zfish    95 -------AVNASKK---------TDISTDESLKSRAETGDQCL-SSDSD---------------- 126

  Fly   386 DLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAA 450
                            .|.:....:..|::|||||||||||||||||  ||:|||||...:.
Zfish   127 ----------------CSQRCAAQAKQPMLWPAWVYCTRYSDRPSSG--PRSRKPKKKTPTK--- 170

  Fly   451 GGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQI 515
                               |||||||||:..||.|||:||..||||||:|||.|:.||||||:||
Zfish   171 -------------------EDKRPRTAFTAEQLQRLKNEFQNNRYLTEQRRQALAQELGLNESQI 216

  Fly   516 KIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEE 558
            ||||||||||:||::|.||.||:.|||||||||:|:  |::::
Zfish   217 KIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHATV--TKDDK 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	40/52 (77%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	15/24 (63%)
en2b	NP_571115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..125		19/93 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..176		17/47 (36%)
		Homeobox	175..228	CDD:278475	40/52 (77%)
		Engrail_1_C_sig	230..259	CDD:287495	16/30 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm6346
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.010