Protein Alignment inv and TLX3

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 66/273 - (24%)
• Similarity: 92/273 - (33%)
• Gaps: 75/273 - (27%)

  Fly   364 NSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGAS--------GKSGEDSGTPIV----W 416
            ||.|.:|..........|      ....||....|||..|        |...||:|:..|    .
Human    25 NSPDQDSAPAPRGPDGAS------YLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLA 83

  Fly   417 PAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGV------------------------ 457
            ||.|.... :.||..|..|.......||..|.......||:
Human    84 PAGVIRVP-AHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTP 147

  Fly   458 -----EKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKI 517
                 ..|........|:.|:|||:||..|:..|:..|:..:||....|..|:..|.:.:||:|.
Human   148 FTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKT 212

  Fly   518 WFQNKRAKLKKSSGTK--------NPLALQLMAQG---------------LYNHSTIPLTREEEE 559
            ||||:|.|.::.:..:        :.|.|||....               |:|.|...|    :.
Human   213 WFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFAL----QN 273

  Fly   560 LQELQEAASAAAA 572
            ||..:|.:|...|
Human   274 LQPWEEDSSKVPA 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	23/55 (42%)
		Engrail_1_C_sig	529..554	CDD:431338	7/47 (15%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		9/36 (25%)
		Homeodomain	167..223	CDD:459649	23/55 (42%)