DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and Hoxd3

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001257967.1	Gene:	Hoxd3 / 288152	RGDID:	1588601	Length:	432	Species:	Rattus norvegicus

Alignment Length:	309	Identity:	80/309 - (25%)
Similarity:	109/309 - (35%)	Gaps:	104/309 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 NILKADFGS-----------RLPKIGALSGNIGGGSVSGSSTGSSKNSGNTN---GNRSPLKAPK 333
            |.|.:|:.|           |.|   |..|....||.....||:|:..|..|   |..|..:.|:
  Rat    57 NSLDSDYPSSACSIQSSAPLRAP---AHKGAELNGSCMRPGTGNSQGGGGGNQPPGLNSEQQPPQ 118

  Fly   334 KSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNT-SGAPVDLVKSPPPAAGA 397
            ....|                               .|...||.||. ||.|....|..|.|:.:
  Rat   119 PPPPP-------------------------------PTLPPSSPTNPGSGVPAKKTKGGPNASSS 152

  Fly   398 GATGASGKSGEDSGTPIVWPAWVYCTRYSDR-----PSSGRSPRARKPKKPATSSSAAGGGGGGV 457
            .:|.:..          ::| |:..:|.:.:     .:||.:...:.|..||:
  Rat   153 SSTISKQ----------IFP-WMKESRQNSKQKNSCATSGENCEDKSPPGPAS------------ 194

  Fly   458 EKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNK 522
                          ||.|||::..||..|:.||:.||||...||.:::..|.|.|.||||||||:
  Rat   195 --------------KRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNR 245

  Fly   523 RAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEEELQELQEAASAAA 571
            |.|.||....|..|           ||  |..:..|....|..||...|
  Rat   246 RMKYKKDQKAKGIL-----------HS--PAGQSPERSPPLGGAAGHVA 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	27/52 (52%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	5/24 (21%)
Hoxd3	NP_001257967.1	Homeobox	198..251	CDD:395001	27/52 (52%)
Hoxd3	NP_001257967.1	DUF4074	369..430	CDD:404218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000