Protein Alignment inv and GBX2

DIOPT Version :9

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 90/416 - (21%)
• Similarity: 138/416 - (33%)
• Gaps: 167/416 - (40%)

  Fly   132 YRPSAFSSTATTVLPPSEGPPFS-PEDLLQ--LPPSTGTFQEEFLRKSQLYAEELMKQQMHLMAA 193
            |||        .||||...||.: |:..||  |||:                     ...|.:.:
Human    50 YRP--------VVLPPPPPPPPALPQAALQPALPPA---------------------HPHHQIPS 85

  Fly   194 ARVNALTAAAAGKQLQMAMAAAAVATVPSGQDALAQLTATALGLG------PGGAVHPHQQLLLQ 252
            ......::.|.|    ||:.:..:||:|.|..|..|....|....      |||.
Human    86 LPTGFCSSLAQG----MALTSTLMATLPGGFSASPQHQEAAAARKFAPQPLPGGG---------- 136

  Fly   253 RDQVHHHHHMQNHLNNNENLHERALKFSIDNILKADFGSR---LPKIGALSGNIGGGSVSGSSTG 314
                                     .|.....|:||....   |.|.|:|.......:|..|..|
Human   137 -------------------------NFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASLVG 176

  Fly   315 SSKNSGNTNGNRSPLKAPKKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTN 379
            :.:..|.   :.|.::...| ||     :.:.:..|.:.:||          |.|.|..::....
Human   177 AVRGQGK---DESKVEDDPK-GK-----EESFSLESDVDYSS----------DDNLTGQAAHKEE 222

  Fly   380 TSGAPVDLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPA 444
            ..|..::  ::||.:..||:|.::||
Human   223 DPGHALE--ETPPSSGAAGSTTSTGK--------------------------------------- 246

  Fly   445 TSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELG 509
                                      ::|.||||:..||..|:.||:..:||:...|.|::..|.
Human   247 --------------------------NRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALK 285

  Fly   510 LNEAQIKIWFQNKRAKLKK-SSGTKN 534
            |:|.|:||||||:|||.|: .:|..|
Human   286 LSEVQVKIWFQNRRAKWKRVKAGNAN 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	26/52 (50%)
		Engrail_1_C_sig	529..554	CDD:287495	2/6 (33%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		7/62 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		20/157 (13%)
		Homeobox	250..303	CDD:306543	26/52 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910