Protein Alignment inv and EN2

DIOPT Version :9

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001418.2
• Gene: EN2 / 2020
• HGNCID: 3343
• Length: 333
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 141/377 - (37%)
• Similarity: 172/377 - (45%)
• Gaps: 103/377 - (27%)

  Fly   213 AAAAV------ATVPSGQDALAQLTATALGLGPGGAVHPHQ-----------QLLLQRDQVHHHH 260
            |||||      .:.|.|            |.|.||...|.:           ..:||....|.|.
Human    11 AAAAVEGQRQPESSPGG------------GSGGGGGSSPGEADTGRRRALMLPAVLQAPGNHQHP 63

  Fly   261 HMQNHLNNNENLHERALKFSIDNILKADFGSRLPK----IGALSGNIGGGSVSGSSTGSSKNSGN 321
            |             |...|.|||||:.:||.|...    .||..|..||....|.::|:....|.
Human    64 H-------------RITNFFIDNILRPEFGRRKDAGTCCAGAGGGRGGGAGGEGGASGAEGGGGA 115

  Fly   322 -------TNGNRSPLKAP---KKSGKPLNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSS 376
                   .:|:|.|.:.|   ..:|.||..|.|::..:.            ...:.:.|....:.
Human   116 GGSEQLLGSGSREPRQNPPCAPGAGGPLPAAGSDSPGDG------------EGGSKTLSLHGGAK 168

  Fly   377 TTNTSGAPVDLVKSPPPAAGAGATGASGKSGEDS--------GTPIVWPAWVYCTRYSDRPSSGR 433
            .....|.|:|   ....|.|.|....|..|..||        ..|::|||||||||||||||||
Human   169 KGGDPGGPLD---GSLKARGLGGGDLSVSSDSDSSQAGANLGAQPMLWPAWVYCTRYSDRPSSG- 229

  Fly   434 SPRARKPKKPATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTE 498
             ||:|||||...:.                      |||||||||:..||.|||.||..||||||
Human   230 -PRSRKPKKKNPNK----------------------EDKRPRTAFTAEQLQRLKAEFQTNRYLTE 271

  Fly   499 KRRQQLSGELGLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHST 550
            :|||.|:.||.|||:||||||||||||:||::|.||.||:.|||||||||||
Human   272 QRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHST 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	39/52 (75%)
		Engrail_1_C_sig	529..554	CDD:287495	16/22 (73%)
EN2	NP_001418.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..206		26/125 (21%)
		homeobox domain	243..302		44/58 (76%)
		Homeobox	247..300	CDD:306543	39/52 (75%)
		Engrail_1_C_sig	302..331	CDD:313702	16/22 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3904
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm8573
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2569
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.090