Protein Alignment inv and NKX6-3

DIOPT Version :10

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001351770.1
• Gene: NKX6-3 / 157848
• HGNCID: 26328
• Length: 265
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 55/215 - (25%)
• Similarity: 83/215 - (38%)
• Gaps: 44/215 - (20%)

  Fly   340 NLAQSNAAANSSLS-FSSSLANICSNSNDSN-------------STATSSSTTNTSGAPV----- 385
            ||..:....|:.|: |....|.:|..|..::             :..|....|:....||
Human     4 NLQGTFLLNNTPLAQFPEMKAPVCQYSVQNSFYKLSPPGLGPQLAAGTPHGITDILSRPVAAPNN 68

  Fly   386 DLVKSPPPAAGAGATGASGKSGEDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAA 450
            .|:...|..||.|...:.|               ||   ||  |..|...:|.......|.:..|
Human    69 SLLSGYPHVAGFGGLSSQG---------------VY---YS--PQVGNFSKAGNEYPTRTRNCWA 113

  Fly   451 GGG---GGGVEKGEAAD--GGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGL 510
            ..|   .||.:.....|  ...:.:.|..|..|:|.|:..|:..|.:.:||....|.:|:..||:
Human   114 DTGQDWRGGRQCSNTPDPLSDSIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGM 178

  Fly   511 NEAQIKIWFQNKRAKLKKSS 530
            .|:|:|:||||:|.|.:|.|
Human   179 TESQVKVWFQNRRTKWRKKS 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeodomain	472..528	CDD:459649	22/55 (40%)
		Engrail_1_C_sig	529..554	CDD:431338	1/2 (50%)
NKX6-3	NP_001351770.1	Homeodomain	138..196	CDD:459649	22/57 (39%)