Protein Alignment inv and En1

DIOPT Version :9

• Sequence 1: NP_523699.3
• Gene: inv / 36239
• FlyBaseID: FBgn0001269
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_034263.2
• Gene: En1 / 13798
• MGIID: 95389
• Length: 401
• Species: Mus musculus
• Alignment Length: 440
• Identity: 149/440 - (33%)
• Similarity: 199/440 - (45%)
• Gaps: 106/440 - (24%)

  Fly   184 MKQQMHLMAAARVNALTAAAAGKQLQMAMAAAAVATVPSGQDALAQLTATALGLGPGGAVHPHQQ 248
            |::|.....:.|.:.|.|.||.....::::.:..|:..||.|.    .:..:...|.....|...
Mouse     1 MEEQQPEPKSQRDSGLGAVAAAAPSGLSLSLSPGASGSSGSDG----DSVPVSPQPAPPSPPAAP 61

  Fly   249 LLLQRDQVHHHHHMQNH---------------------LNNNENLHERALKFSIDNILKADFGSR 292
            .|   ..:.||.|:..|                     ......|| |...|.|||||:.|||.:
Mouse    62 CL---PPLAHHPHLPPHPPPPPPPPPPPPQHLAAPAHQPQPAAQLH-RTTNFFIDNILRPDFGCK 122

  Fly   293 ----LPKIGALSGNIGGGSVSGSSTGSSKNSGNTNGNRSP--------------LKAPKKSGKPL 339
                ||::...|...|||:.:|..:...::.|.|...|.|              |.||..:..|.
Mouse   123 KEQPLPQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVHSLGTRASGAASLLCAPDANCGPP 187

  Fly   340 NLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDLVKSPPPAAGAGATGASG 404
            :.:|...|.::..|         ...|.:.:.|.:::....:.|......|.|..:|.|:.|.:|
Mouse   188 DGSQPATAVSAGAS---------KAGNPAAAAAAAAAAAAAAVAAAAAAASKPSDSGGGSGGNAG 243

  Fly   405 KSG--------------------------EDSGTPIVWPAWVYCTRYSDRPSSGRSPRARKPKKP 443
            ..|                          .||..|:||||||||||||||||||  ||.||.||
Mouse   244 SPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSG--PRTRKLKK- 305

  Fly   444 ATSSSAAGGGGGGVEKGEAADGGGVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGEL 508
                          :|.|       .|||||||||:..||.|||.||..|||:||:|||.|:.||
Mouse   306 --------------KKNE-------KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQEL 349

  Fly   509 GLNEAQIKIWFQNKRAKLKKSSGTKNPLALQLMAQGLYNHSTIPLTREEE 558
            .|||:||||||||||||:||::|.||.|||.|||||||||||..:..::|
Mouse   350 SLNESQIKIWFQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDE 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	38/52 (73%)
		Engrail_1_C_sig	529..554	CDD:287495	17/24 (71%)
En1	NP_034263.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102		18/107 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..167		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..253		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		16/45 (36%)
		Homeobox	315..368	CDD:278475	38/52 (73%)
		Engrail_1_C_sig	370..399	CDD:287495	17/28 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834692
Domainoid	1	1.000	94	1.000	Domainoid score	I7450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm8801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2569
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970