DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and CPHXL

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001342542.1	Gene:	CPHXL / 105371346	HGNCID:	51815	Length:	405	Species:	Homo sapiens

Alignment Length:	135	Identity:	37/135 - (27%)
Similarity:	49/135 - (36%)	Gaps:	38/135 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 DG--GGVPEDK---------------RPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLN 511
            ||  ||.|.::               :.|..||...|..||..|.||.|.....|:.|:.:....
Human     4 DGTSGGFPAEEDHHNEERQTKNKRKTKHRHKFSEELLQELKEIFGENCYPDYTTRKTLAIKFDCP 68

  Fly   512 EAQIKIWFQNKRAKLKKSS-------GTKNPLALQLMAQGLYNHSTIPLTREEEELQELQEAASA 569
            ...|..|||||||:|..:.       ..|:...:|.       ||.:       ..||.|.||..
Human    69 VNVIDNWFQNKRARLPPAERRRIFVLQKKHDFPVQA-------HSFL-------SCQETQAAAHN 119

  Fly   570 AAAKE 574
            .|.|:
Human   120 YATKQ 124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	20/52 (38%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	4/31 (13%)
CPHXL	NP_001342542.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/28 (18%)
		HOX	28..82	CDD:197696	19/53 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24341
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030