DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inv and hoxc3

DIOPT Version :9

Sequence 1:	NP_523699.3	Gene:	inv / 36239	FlyBaseID:	FBgn0001269	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_002936696.1	Gene:	hoxc3 / 100190990	XenbaseID:	XB-GENE-5997986	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	306	Identity:	83/306 - (27%)
Similarity:	112/306 - (36%)	Gaps:	84/306 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 DNILKADFGSRLPKIGALSGNIGGGSVSGSSTGSSKN--------SGNTNGNRSPLKAPKKSGKP 338
            ||  .|.||.     ....||.|.|.:......|..:        ....||:.|........|..
Frog    10 DN--SASFGG-----CGFQGNNGMGYLGQQDYPSEDDYQPPFCLPPDTANGSASHKGEHSIKGID 67

  Fly   339 LNLAQSNAAANSSLSFSSSLANICSNSNDSNSTATSSSTTNTSGAPVDL-VKSPPPAAGAGATGA 402
            .:|::.:..|....|.:       |:|....|.:|.|.|:..|..||.. |.||
Frog    68 FHLSEVSEQAQQPKSPN-------SDSPLPKSASTQSCTSKKSTGPVSSDVTSP----------- 114

  Fly   403 SGKSGEDSGTP-IVWPAWVYCTRYSDRPSSGRSPRARKPKKPATSSSAAGGGGGGVEKGEAADGG 466
             .|..:.|..| .::| |:..||.:.:......|.|  ...||..||.....
Frog   115 -NKKSKGSNMPKQIFP-WMKETRQNSKQKKQAPPPA--DDAPAVDSSFLSSA------------- 162

  Fly   467 GVPEDKRPRTAFSGTQLARLKHEFNENRYLTEKRRQQLSGELGLNEAQIKIWFQNKRAKLKK--- 528
                .||.|||::.:||..|:.||:.||||...||.:::..|.|:|.||||||||:|.|.||
Frog   163 ----SKRARTAYTNSQLVELEKEFHFNRYLCRPRRLEMAKLLNLSERQIKIWFQNRRMKFKKDHK 223

  Fly   529 --------------SSGTKNPLALQL-----------MAQGLYNHS 549
                          ||.:..|.:..|           ||.|.||.|
Frog   224 GKGGGGSPGGLSPSSSPSLMPYSGNLPLDGDCGYEVPMATGAYNKS 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inv	NP_523699.3	Homeobox	474..527	CDD:278475	27/52 (52%)
inv	NP_523699.3	Engrail_1_C_sig	529..554	CDD:287495	10/32 (31%)
hoxc3	XP_002936696.1	Homeobox	167..220	CDD:395001	27/52 (52%)
hoxc3	XP_002936696.1	DUF4074	335..392	CDD:404218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910