DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(Pc) and EPC1

DIOPT Version :9

Sequence 1:NP_001260897.1 Gene:E(Pc) / 36238 FlyBaseID:FBgn0000581 Length:2097 Species:Drosophila melanogaster
Sequence 2:NP_079485.1 Gene:EPC1 / 80314 HGNCID:19876 Length:836 Species:Homo sapiens


Alignment Length:1034 Identity:318/1034 - (30%)
Similarity:467/1034 - (45%) Gaps:287/1034 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICT---- 61
            |||||||||.||.||.:|::..|:||||.||::|||||||||:||||||||||||||||..    
Human     1 MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVY 65

  Fly    62 -----GLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQ-Q 120
                 .::||.||. :::..:|::.||.::|||:|:||:||..||.|.||||:||.||.:::: :
Human    66 GEKRDNMVIPVPEA-ESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLK 129

  Fly   121 QRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHP-LILTV 184
            :::::..|:||:|:|||||.|||..|:|.|||.||.:|||....||:||:.||...:.| ||.:|
Human   130 KKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKNCRGPSLIPSV 194

  Fly   185 KTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKR 249
            |.|.|.|:|:|:||:||||||||||||||||||||||||||||||||.||.|||||::|||::||
Human   195 KQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKR 259

  Fly   250 DHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPT 314
            :.|.:|:.|.|||..:.|:||.:.||:.:|.:..:|.|                       |:| 
Human   260 ELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTY-----------------------AIP- 300

  Fly   315 GLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQ 379
             ::|           ..::||:.:..  .||.           ||.:..|:.|..|.|.|:::: 
Human   301 -IIP-----------ITNSSQFKHQE--AMDV-----------KEFKVNKQDKADLIRPKRKYE- 339

  Fly   380 QQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAA---------NDSIADSEEEDYF 435
                  ::.:.||:|  |..:|              |..||||         |.....|.:|:..
Human   340 ------KKPKVLPSS--AAATP--------------QQTSPAALPVFNAKDLNQYDFPSSDEEPL 382

  Fly   436 GAGAQNGNKLGSESEEETPFAFRRRSSC-VYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTL 499
            .......::...:::.:.||||||::.| .|.|...:.|.:||.|..:     |...|.:|||.|
Human   383 SQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKD-----GGLGDVRYRYCL 442

  Fly   500 TSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKQRDPDQL 564
            |:|..|: |||||||||:|||||:|||||.:::|..:..||..::.|                  
Human   443 TTLTVPQ-RCIGFARRRVGRGGRVLLDRAHSDYDSVFHHLDLEMLSS------------------ 488

  Fly   565 CKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKFENDVDD 629
                         |...||:                        :....|:....::.|..|:..
Human   489 -------------PQHSPVN------------------------QFANTSETNTSDKSFSKDLSQ 516

  Fly   630 EFV------------------ASDDENVSRLGIYSS------AVTLPQSCADLRQKRRRLRRKKQ 670
            ..|                  .||::.:|...:|.|      |....|:|:...|          
Human   517 ILVNIKSCRWRHFRPRTPSLHDSDNDELSCRKLYRSINRTGTAQPGTQTCSTSTQ---------- 571

  Fly   671 QLRELNAAKRLKRSSEAVATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVS 735
                   :|....|:....|||..|               .:.|:|||:..|:|           
Human   572 -------SKSSSGSAHFAFTAEQYQ---------------QHQQQLALMQKQQL----------- 603

  Fly   736 ENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSS---NVMNKDVSISEKINV 797
                         .|:|..:||      ||.:.|.:..|.:|...|.   |:...:.::...::.
Human   604 -------------AQIQQQQAN------SNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSK 649

  Fly   798 IKQEA------------EELVGGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGP 850
            ....|            |:|:|.|.:|..|.........  .|.........||||..|..:..|
Human   650 TLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVL--PASGVYKGLHLSSTTPTALVHTSP 712

  Fly   851 SLEEVAKTIKREMIDADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSI------ 909
            |....|......:.....|:..||...|||...:||..:.        :::.|...||:      
Human   713 STAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIG--------NNIRLTVPSSVATVNSI 769

  Fly   910 ----IRH----------TAVKKELEAQQHQQQV-QHEQMQAARKMEEDEAAPCLNQLPD 953
                .||          :|:|....|.....:| ....:.:..:...:...|.||.:.|
Human   770 APINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIAD 828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(Pc)NP_001260897.1 EPL1 7..139 CDD:287484 73/141 (52%)
EPC1NP_079485.1 EPL1 7..148 CDD:331339 73/141 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..360 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..401 2/28 (7%)
E_Pc_C 582..836 CDD:310988 58/302 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 802..829 5/27 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156785
Domainoid 1 1.000 157 1.000 Domainoid score I4148
eggNOG 1 0.900 - - E1_KOG2261
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 441 1.000 Inparanoid score I1666
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001287
OrthoInspector 1 1.000 - - otm41609
orthoMCL 1 0.900 - - OOG6_102490
Panther 1 1.100 - - LDO PTHR14898
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R399
SonicParanoid 1 1.000 - - X1679
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.780

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