Protein Alignment E(Pc) and EPC1

DIOPT Version :10

• Sequence 1: NP_001260897.1
• Gene: E(Pc) / 36238
• FlyBaseID: FBgn0000581
• Length: 2097
• Species: Drosophila melanogaster
• Sequence 2: NP_079485.1
• Gene: EPC1 / 80314
• HGNCID: 19876
• Length: 836
• Species: Homo sapiens
• Alignment Length: 1034
• Identity: 318/1034 - (30%)
• Similarity: 467/1034 - (45%)
• Gaps: 287/1034 - (27%)

  Fly     1 MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICT---- 61
            |||||||||.||.||.:|::..|:||||.||::|||||||||:||||||||||||||||..
Human     1 MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVY 65

  Fly    62 -----GLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQ-Q 120
                 .::||.||. :::..:|::.||.::|||:|:||:||..||.|.||||:||.||.:::: :
Human    66 GEKRDNMVIPVPEA-ESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLK 129

  Fly   121 QRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHP-LILTV 184
            :::::..|:||:|:|||||.|||..|:|.|||.||.:|||....||:||:.||...:.| ||.:|
Human   130 KKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKNCRGPSLIPSV 194

  Fly   185 KTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKR 249
            |.|.|.|:|:|:||:||||||||||||||||||||||||||||||||.||.|||||::|||::||
Human   195 KQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKR 259

  Fly   250 DHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPT 314
            :.|.:|:.|.|||..:.|:||.:.||:.:|.:..:|.|                       |:|
Human   260 ELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTY-----------------------AIP- 300

  Fly   315 GLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQ 379
             ::|           ..::||:.:..  .||.           ||.:..|:.|..|.|.|::::
Human   301 -IIP-----------ITNSSQFKHQE--AMDV-----------KEFKVNKQDKADLIRPKRKYE- 339

  Fly   380 QQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAA---------NDSIADSEEEDYF 435
                  ::.:.||:|  |..:|              |..||||         |.....|.:|:..
Human   340 ------KKPKVLPSS--AAATP--------------QQTSPAALPVFNAKDLNQYDFPSSDEEPL 382

  Fly   436 GAGAQNGNKLGSESEEETPFAFRRRSSC-VYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTL 499
            .......::...:::.:.||||||::.| .|.|...:.|.:||.|..:     |...|.:|||.|
Human   383 SQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKD-----GGLGDVRYRYCL 442

  Fly   500 TSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKQRDPDQL 564
            |:|..|: |||||||||:|||||:|||||.:::|..:..||..::.|
Human   443 TTLTVPQ-RCIGFARRRVGRGGRVLLDRAHSDYDSVFHHLDLEMLSS------------------ 488

  Fly   565 CKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEEKFENDVDD 629
                         |...||:                        :....|:....::.|..|:..
Human   489 -------------PQHSPVN------------------------QFANTSETNTSDKSFSKDLSQ 516

  Fly   630 EFV------------------ASDDENVSRLGIYSS------AVTLPQSCADLRQKRRRLRRKKQ 670
            ..|                  .||::.:|...:|.|      |....|:|:...|
Human   517 ILVNIKSCRWRHFRPRTPSLHDSDNDELSCRKLYRSINRTGTAQPGTQTCSTSTQ---------- 571

  Fly   671 QLRELNAAKRLKRSSEAVATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVS 735
                   :|....|:....|||..|               .:.|:|||:..|:|
Human   572 -------SKSSSGSAHFAFTAEQYQ---------------QHQQQLALMQKQQL----------- 603

  Fly   736 ENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSS---NVMNKDVSISEKINV 797
                         .|:|..:||      ||.:.|.:..|.:|...|.   |:...:.::...::.
Human   604 -------------AQIQQQQAN------SNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSK 649

  Fly   798 IKQEA------------EELVGGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGP 850
            ....|            |:|:|.|.:|..|.........  .|.........||||..|..:..|
Human   650 TLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVL--PASGVYKGLHLSSTTPTALVHTSP 712

  Fly   851 SLEEVAKTIKREMIDADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSI------ 909
            |....|......:.....|:..||...|||...:||..:.        :::.|...||:
Human   713 STAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIG--------NNIRLTVPSSVATVNSI 769

  Fly   910 ----IRH----------TAVKKELEAQQHQQQV-QHEQMQAARKMEEDEAAPCLNQLPD 953
                .||          :|:|....|.....:| ....:.:..:...:...|.||.:.|
Human   770 APINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIAD 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(Pc)	NP_001260897.1	EPL1	7..139	CDD:463128	73/141 (52%)
EPC1	NP_079485.1	EPL1	7..148	CDD:463128	73/141 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..360		9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..401		2/28 (7%)
		E_Pc_C	582..836	CDD:462002	58/302 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	802..829		5/27 (19%)