DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(Pc) and epc1b

DIOPT Version :9

Sequence 1:	NP_001260897.1	Gene:	E(Pc) / 36238	FlyBaseID:	FBgn0000581	Length:	2097	Species:	Drosophila melanogaster
Sequence 2:	NP_001082878.1	Gene:	epc1b / 566102	ZFINID:	ZDB-GENE-090609-1	Length:	797	Species:	Danio rerio

Alignment Length:	987	Identity:	303/987 - (30%)
Similarity:	449/987 - (45%)	Gaps:	270/987 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICT---- 61
            |||||||||.||.||.:|::..|:||||.||::|||||||||:||||||||||||||||..
Zfish     1 MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVY 65

  Fly    62 -----GLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQ-Q 120
                 .::||.||. :::..:|::.||.|:|||:|:||:||..||||.||||:||.||.:::: :
Zfish    66 GEKRDNMVIPVPEA-ESNIAYYESLYPGDFKMPKQLIHIQPFSLDTEQPDYDLDSEDEAFVNKLK 129

  Fly   121 QRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQH-PLILTV 184
            :::::..|:||:|:|||||.|||..|||.|||.||.:|||....|::||..||...|. .||..|
Zfish   130 KKMDVGALQFEEMIDRLEKGSGQQPVTLQEAKLLLKEDDELIKEVFEYWSKKRKTCQSGSLIPVV 194

  Fly   185 KTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKR 249
            |.|.|.|:|:|:||:||||||||||||||||||||||||||||||||.||.|||||::|||::||
Zfish   195 KQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKR 259

  Fly   250 DHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPT 314
            :.|.:|:.|.|||..|.||.|.|.:|:.:|....:|                         .:|
Zfish   260 ELLHLTLEIVEKRNNMSDFGGEVMAEVLAQRALEKP-------------------------VIP- 298

  Fly   315 GLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQ 379
             |:|           ..:::||.::.:                       .|.:|:..||.:..:
Zfish   299 -LIP-----------ITNSTQYRHTEH-----------------------DRDYKIKMDKPEVVR 328

  Fly   380 QQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADSEEEDYFGAGAQNGNK 444
            |:.:..::.:.||.:|.     .|..|...:.....|...|:::|        :.|.......::
Zfish   329 QKRKYEKKPKPLPLAGS-----VHSGPSVFNTKDLNQYDFPSSDD--------EPFSQMFSGSSE 380

  Fly   445 LGSESEEETPFAFRRRSSCVYLPTRQRD-GRYPWDSADEDMAPSGACSDAKYRYTLTSLNYPRPR 508
            :..|::.:..|.||||:.|.|...|... ..:||....|     |..:|.:|||:||:|..|| |
Zfish   381 VEEENDPDGVFGFRRRTGCQYHSARSGPVSGWPWSDPAE-----GGVADVRYRYSLTTLTVPR-R 439

  Fly   509 CIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIKQRDPDQLCKPSSPPTV 573
            |:|.||||:|||||:|||||.:.:|..:..|                    |||....||..||
Zfish   440 CLGLARRRVGRGGRVLLDRAHSEWDTVYHGL--------------------DPDSPAFPSLSPT- 483

  Fly   574 VDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEE--------KFENDVDDE 630
                                :::||:||......| |...:...:|.:        ::.:.....
Zfish   484 --------------------QQQPSTDTSHTSTDT-SAPSATPPDLTQILLNIKACRWRHFKPRT 527

  Fly   631 FVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLK---RSSEAVATAE 692
            ....|.:|             |:..:..|.:|..|.|..:.|:.......::   .......|||
Zfish   528 APPDDPDN-------------PEHWSTRRPRRGFLIRPIRTLQTQRGPASIRPPPPPPTPAFTAE 579

  Fly   693 DVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVSENVAPELLEMNDPEQLQPPRAN 757
            ..|...|.                 |:|.||.::                      ||:|    .
Zfish   580 QYQQHQEQ-----------------LVLMQKQQL----------------------EQVQ----Q 601

  Fly   758 HQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQEAEELVGGKCEDQPVA------ 816
            |||...|...||..::::....::|........::.         |:|:..|.:|:.|.
Zfish   602 HQQTGSSAVTNNPQSLVSKTIDAASAQFAASALVTH---------EQLLALKSKDEGVGVNGVVS 657

  Fly   817 ---------STSAAAAAARAAEAAAAAEAAS---STTT------------LAAPNPGPSLEEVA- 856
                     .||:|.::...:..:.:....|   :|||            .|.|.||.:|...|
Zfish   658 ASGVYKGLHHTSSAVSSILPSVGSTSTSCPSPTIATTTNNGTSSANHHVGPAGPAPGQALMGGAV 722

  Fly   857 -------------KTIKREMID-------ADDSNEPLSSIRTAAVMLSTQTSVSELMDDEAEDDV 901
                         :.::|::..       |.::|.||..:.|.:..|.        |......|.
Zfish   723 RVSVPSPAGTLSVRQLQRQLTVPASALKLAANANRPLPKVTTGSTTLD--------MGPRENHDQ 779

  Fly   902 NLAQLSSIIRHT 913
            ....|:|:..:|
Zfish   780 EKPPLNSLTENT 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(Pc)	NP_001260897.1	EPL1	7..139	CDD:287484	75/141 (53%)
epc1b	NP_001082878.1	EPL1	7..148	CDD:287484	75/141 (53%)
epc1b	NP_001082878.1	E_Pc_C	575..797	CDD:284226	49/277 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592427
Domainoid	1	1.000	160	1.000	Domainoid score	I4017
eggNOG	1	0.900	-	-		E1_KOG2261
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1778
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001287
OrthoInspector	1	1.000	-	-		otm24238
orthoMCL	1	0.900	-	-		OOG6_102490
Panther	1	1.100	-	-	LDO	PTHR14898
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R399
SonicParanoid	1	1.000	-	-		X1679
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780