DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(Pc) and Epc2

DIOPT Version :9

Sequence 1:	NP_001260897.1	Gene:	E(Pc) / 36238	FlyBaseID:	FBgn0000581	Length:	2097	Species:	Drosophila melanogaster
Sequence 2:	NP_001102051.1	Gene:	Epc2 / 362132	RGDID:	1307271	Length:	808	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	287/966 - (29%)
Similarity:	431/966 - (44%)	Gaps:	244/966 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICT---- 61
            |||||||||.||.:|.:|||..:::|||.:..:|||||||||:||||||||||||||||..
  Rat     1 MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVF 65

  Fly    62 -----GLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQ-Q 120
                 .::||.||. :::..:|:..|..::|.|:|.||:||..||.|.|||||||.||..|:: .
  Rat    66 REKKESMVIPVPEA-ESNVNYYNRLYKGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLN 129

  Fly   121 QRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHP-LILTV 184
            :::|:..|:||.|:|||||:|...:|||.|||.|||:||....:|||||:.||...:.| ||..:
  Rat   130 RKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIPQI 194

  Fly   185 KTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKR 249
            |.|.|.|:::|:||:||||||||||||||||||||||||||||||:..||.|||||::|||:|||
  Rat   195 KQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKR 259

  Fly   250 DHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPT 314
            :.|.:|:.:.|||..:.|:.|.:.:|:.                        |..:...|.|.|.
  Rat   260 ELLHLTLEVVEKRYHLGDYGGEILNEVK------------------------VNRSEKELYASPA 300

  Fly   315 GLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSR----KEKRPY----KKRKHKLP 371
            .|                                  .|||..:    |.|.|:    |:....:.
  Rat   301 TL----------------------------------HNGNHHKVQECKTKHPHHLSLKEEASDVV 331

  Fly   372 RDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIA-----DSEE 431
            |.|::|.::...:            |.::|....|..:          |..|.|..     .|.:
  Rat   332 RQKKKHPKKPKAE------------AVLAPPQPTPETV----------PVINKSDIKQYDFQSSD 374

  Fly   432 EDYFGAGAQNGNKLGSESEEETPFAFRRRSSC-VYLPTRQRDGRYPWDS---ADEDMAPSGACSD 492
            ||.|.......::...|::.:.|.|||||:.| .|.|...:...:|.:|   ||.|        .
  Rat   375 EDEFPQVPSPASEPEEENDPDGPCAFRRRAGCQYYAPRLDQANNHPCESSELADLD--------K 431

  Fly   493 AKYRYTLTSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKIK 557
            .:|::.||:|..|| |||||||||:|||||:::||.:|..|..                    :|
  Rat   432 LRYKHCLTTLTVPR-RCIGFARRRIGRGGRVIMDRISTEHDPV--------------------LK 475

  Fly   558 QRDPDQLCKPSSPPTVVDLV-------PAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESK 615
            |.||:.|...||....:|..       .:.||.:....:.|::               .:.|..:
  Rat   476 QIDPEMLNGLSSSSQTIDFSSNFSRTNASSKPCENRLSLSEIL---------------SNIRSCR 525

  Fly   616 ERELEEKFEN--DVDDEFVAS--DDENVSRLGIYSSAVTLPQSCAD-------------LRQKRR 663
            .:..:.:..|  |:|.|...|  ..:.||...:.:::|.|..:..:             ...:::
  Rat   526 LQCFQPRLLNVQDIDSEECTSRKPGQTVSSKRVSAASVALLNTSKNGISVTGGITEEQFQTHQQQ 590

  Fly   664 RLRRKKQQLRELNAAKRLKRSSEAV------ATAEDVQLEDEDTKPDLRPLPRAYLQRLALILGQ 722
            ..:.::|||.:|...::.:.||:..      ::..|...:..|:       ..|:....|::
  Rat   591 LAQMQRQQLAQLQQKQQSQHSSQQTHPKAQGSSTSDCMSKTLDS-------ASAHFAASAVV--- 645

  Fly   723 KLKVEEDDNTEVSENVAPELLEMNDPEQLQPPRANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNK 787
                           .||           .|.|:...:...:.|||.|..|..:..|.:....|.
  Rat   646 ---------------SAP-----------VPSRSEGSKEQNTGHNNMNGVVQPSGPSKTLYSTNM 684

  Fly   788 DVSISEKINVIK-------QEAEELVGGKCEDQPVA---STSAAAAAARAAEAAAAA-------- 834
            .:|.|..|:.::       .....|:...|...|..   :.|....|......:..:
  Rat   685 ALSSSPGISAVQLVRTVGHTTTNHLIPALCTSSPQTLPMNNSCLTNAVHLNNVSVVSPVNVHINT 749

  Fly   835 -EAASSTTTLAAPNPGPSLEEVAKTIKREMID--ADDSNEP----LSSIRTAAVML 883
             .:|.|.|.|.......|::.|.|......|.  |.:::||    |:.|....|.:
  Rat   750 RTSAPSPTALKLATVAASMDRVPKVTPSSAISSIARENHEPERLGLNGIAETTVAM 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(Pc)	NP_001260897.1	EPL1	7..139	CDD:287484	71/141 (50%)
Epc2	NP_001102051.1	EPL1	7..148	CDD:287484	71/141 (50%)
Epc2	NP_001102051.1	E_Pc_C	578..808	CDD:284226	43/264 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350710
Domainoid	1	1.000	143	1.000	Domainoid score	I4542
eggNOG	1	0.900	-	-		E1_KOG2261
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001287
OrthoInspector	1	1.000	-	-		otm45731
orthoMCL	1	0.900	-	-		OOG6_102490
Panther	1	1.100	-	-	O	PTHR14898
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1679
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.700