DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(Pc) and EPC2

DIOPT Version :9

Sequence 1:	NP_001260897.1	Gene:	E(Pc) / 36238	FlyBaseID:	FBgn0000581	Length:	2097	Species:	Drosophila melanogaster
Sequence 2:	NP_056445.3	Gene:	EPC2 / 26122	HGNCID:	24543	Length:	807	Species:	Homo sapiens

Alignment Length:	1034	Identity:	298/1034 - (28%)
Similarity:	430/1034 - (41%)	Gaps:	317/1034 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICT---- 61
            |||||||||.||.:|.:|||..:::|||.:..:|||||||||:||||||||||||||||..
Human     1 MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVF 65

  Fly    62 -----GLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQ-Q 120
                 .::||.||. :::..:|:..|..::|.|:|.||:||..||.|.|||||||.||..|:: .
Human    66 REKKESMVIPVPEA-ESNVNYYNRLYKGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLN 129

  Fly   121 QRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQHP-LILTV 184
            :::|:..|:||.|:|||||:|...:|||.|||.|||:||....:|||||:.||...:.| ||..:
Human   130 RKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIPQI 194

  Fly   185 KTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKR 249
            |.|.|.|:::|:||:||||||||||||||||||||||||||||||:..||.|||||::|||:|||
Human   195 KQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKR 259

  Fly   250 DHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPT 314
            :.|.:|:.:.|||..:.|:.|.:.:|:.                        :..:...|.|.|.
Human   260 ELLHLTLEVVEKRYHLGDYGGEILNEVK------------------------ISRSEKELYATPA 300

  Fly   315 GLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSR----KEKRPYK----------- 364
            .|                                  .|||..:    |.|.|:.
Human   301 TL----------------------------------HNGNHHKVQECKTKHPHHLSLKEEASDVV 331

  Fly   365 KRKHKLPRDKQQHQQQQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADS 429
            ::|.|.|: |.:.:...|.|....:.||....:.:.     .:..|  |..:...|.....:::.
Human   332 RQKKKYPK-KPKAEALITSQQPTPETLPVINKSDIK-----QYDFH--SSDEDEFPQVLSPVSEP 388

  Fly   430 EEEDYFGAGAQNGNKLGSESEEETPFAFRRRSSCVYLPTRQRDGRYPWDS---ADEDMAPSGACS 491
            ||                |::.:.|.|||||:.|.|...|.....:..::   ||.|
Human   389 EE----------------ENDPDGPCAFRRRAGCQYYAPRLDQANHSCENSELADLD-------- 429

  Fly   492 DAKYRYTLTSLNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMESVTVNKCRDKI 556
            ..:||:.||:|..|| |||||||||:|||||:::||.:|..|..                    :
Human   430 KLRYRHCLTTLTVPR-RCIGFARRRIGRGGRVIMDRISTEHDPV--------------------L 473

  Fly   557 KQRDPDQLCKPSSPPTVVDLVPAGKPVDGEHPVPELIKEEPSSDTEKPVAATESGRESKERELEE 621
            ||.||:.|...||....:|.
Human   474 KQIDPEMLNSFSSSSQTIDF--------------------------------------------- 493

  Fly   622 KFENDVDDEFVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLKRSSE 686
                          ..|.||....|.......|.:::....|..|.:..|.|.||
Human   494 --------------SSNFSRTNASSKHCENRLSLSEILSNIRSCRLQCFQPRLLN---------- 534

  Fly   687 AVATAEDVQLEDEDTKPDLRPLP-------RAYLQRLALILGQKLKVEEDDNTEVSENVAPELLE 744
                     |:|.|::......|       |.....:||:...|      :...|:..:..|..:
Human   535 ---------LQDSDSEECTSRKPGQTVNNKRVSAASVALLNTSK------NGISVTGGITEEQFQ 584

  Fly   745 MNDPEQLQPPR---ANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQEAEELV 806
            .:..:.:|..|   |..||..:|.| ::..|......||:|:.|:|
Human   585 THQQQLVQMQRQQLAQLQQKQQSQH-SSQQTHPKAQGSSTSDCMSK------------------- 629

  Fly   807 GGKCEDQPVASTSAAAAAARAAEAAAAAEAASSTTTLAAPNPGPSLEEVAKTIKREMIDADDSNE 871
                       |..:|:|..||.|..:|             |.||..|||   |.:....::.|.
Human   630 -----------TLDSASAHFAASAVVSA-------------PVPSRSEVA---KEQNTGHNNING 667

  Fly   872 PLSSIRTAAVMLSTQTSVSELMDDEAEDDVNLAQLSSIIRHTAVKKELEAQQHQQQVQHEQMQAA 936
            .:....|:..:.||..::|      :...::..||...:.||..               ..:..|
Human   668 VVQPSGTSKTLYSTNMALS------SSPGISAVQLVRTVGHTTT---------------NHLIPA 711

  Fly   937 RKMEEDEAAPCLNQ-LPDVIRLRNIRNSQVHARPKDLFVQAPVDEEFNADYMGGLSPTS 994
            ......:..|..|. |.:.:.|.|:.            |.:||:...|. .....|||:
Human   712 LCTSSPQTLPMNNSCLTNAVHLNNVS------------VVSPVNVHINT-RTSAPSPTA 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(Pc)	NP_001260897.1	EPL1	7..139	CDD:287484	71/141 (50%)
EPC2	NP_056445.3	EPL1	7..148	CDD:287484	71/141 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..396		4/35 (11%)
		E_Pc_C	577..807	CDD:284226	50/262 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..628		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..673		9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156786
Domainoid	1	1.000	157	1.000	Domainoid score	I4148
eggNOG	1	0.900	-	-		E1_KOG2261
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1666
Isobase	1	0.950	-	0	Normalized mean entropy	S4694
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001287
OrthoInspector	1	1.000	-	-		otm41609
orthoMCL	1	0.900	-	-		OOG6_102490
Panther	1	1.100	-	-	O	PTHR14898
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1679
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.700