DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(Pc) and Epc1

DIOPT Version :9

Sequence 1:	NP_001260897.1	Gene:	E(Pc) / 36238	FlyBaseID:	FBgn0000581	Length:	2097	Species:	Drosophila melanogaster
Sequence 2:	NP_081773.1	Gene:	Epc1 / 13831	MGIID:	1278322	Length:	813	Species:	Mus musculus

Alignment Length:	988	Identity:	314/988 - (31%)
Similarity:	464/988 - (46%)	Gaps:	287/988 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKLSFRARHLDPSKQMPIYLAEELPDLPEYSAINRAVPQMPSGMEKEEESEHHLQRAICT---- 61
            |||||||||.||.||.:|::..|:||||.||::|||||||||:||||||||||||||||..
Mouse     1 MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVY 65

  Fly    62 -----GLIIPTPEVLQTDQPFYDAYYPPDYKMPRQMIHMQPLGLDTEVPDYDMDSADEDWLSQ-Q 120
                 .::||.||. :::..:|::.||.:::||:|:||:||..||.|.||||:||.||.:::: :
Mouse    66 GEKRDNMVIPVPEA-ESNIAYYESIYPGEFRMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLK 129

  Fly   121 QRLELTELKFEQMMDRLEKSSGQTVVTLNEAKSLLNQDDETSISVYDYWLNKRLKMQ-HPLILTV 184
            :::::..|:||:|:|||||.|||..|:|.|||.||.:|||....||:||:.||...: ..||..|
Mouse   130 KKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLV 194

  Fly   185 KTESRPGASSNNPYLAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLQRATTILEMVRRREETKR 249
            |.|.|.|:|:|:||:||||||||||||||||||||||||||||||||.||.|||||::|||::||
Mouse   195 KQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKR 259

  Fly   250 DHLKMTVNIFEKRVEMRDFNGAVYSELNSQYKNTRPAYNPLYTNQYSQGAAAVGTAGAILAALPT 314
            :.|.:|:.|.|||..:.|::|.:.||:.:|.:..:|.|                       |:|
Mouse   260 ELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTY-----------------------AIP- 300

  Fly   315 GLLPGGAGAAGNANVFGSASQYLNSSNLTMDAISGSGNGNSSRKEKRPYKKRKHKLPRDKQQHQQ 379
             ::|           ..::||:.:     .||        :..||.:..|:.|..|.|.|::::
Mouse   301 -IIP-----------ITNSSQFKH-----QDA--------TDSKEFKVNKQDKADLIRPKRKYE- 339

  Fly   380 QQTQQHQQQQYLPASGGAGVSPAHHLPHHLHHLSRQQSASPAANDSIADSEEEDYFGAGAQNGNK 444
                  ::.:.||.|..|               .:|||.:.....|..|..:.|:..:..:..::
Mouse   340 ------KKPKVLPPSAAA---------------PQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQ 383

  Fly   445 L---GSESEEET----PFAFRRRSSC-VYLPTRQRDGRYPWDSADEDMAPSGACSDAKYRYTLTS 501
            :   .||:|||.    ||||||::.| .|.|...:.|.:||.|..:     |...|.:|||.||:
Mouse   384 VLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKD-----GGLGDVRYRYCLTT 443

  Fly   502 LNYPRPRCIGFARRRLGRGGRILLDRATTNFDDFWSQLDYTVMES---VTVNKCRDKIKQRDPDQ 563
            |..|: ||:||||||:|||||::||||.:::|..:..||..::.|   ..||:..:..:....|:
Mouse   444 LTVPQ-RCLGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSEPNTSDR 507

  Fly   564 LCKPSSPPTVVDLVPAGKPVDGEH---PVPELIKEEPSSDTEKPVAATESGRESKERELEEKFEN 625
            .........:||:    |.....|   ..|.|    |.||         || |...|:|.
Mouse   508 SSSKDLSQILVDI----KSCRWRHFRPRTPSL----PDSD---------SG-ELSSRKLH----- 549

  Fly   626 DVDDEFVASDDENVSRLGIYSSAVTLPQSCADLRQKRRRLRRKKQQLRELNAAKRLKRSSEAVAT 690
                       .::||.|   :|.....:|:...|.|..                 ..|:....|
Mouse   550 -----------RSISRAG---AAQPGAHTCSTSTQNRSS-----------------SGSAHCAFT 583

  Fly   691 AEDVQLEDEDTKPDLRPLPRAYLQRLALILGQKLKVEEDDNTEVSENVAPELLEMNDPEQLQPPR 755
            ||..|               .:.|:|||:..|:|
Mouse   584 AEQYQ---------------QHQQQLALMQQQQL------------------------------- 602

  Fly   756 ANHQQHHRSNHNNNNNTVLNNNNSSSSNVMNKDVSISEKINVIKQE--------AEELVGGKCED 812
            |..||..::|              |||:...:...:|:.::....:        :|:|:|.|.:|
Mouse   603 AQTQQQQQAN--------------SSSSAAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKD 653

  Fly   813 QPV--------------------ASTSAAAAAARAAEAAAA---------------------AEA 836
            ..|                    :||:..|....:...|.:                     ..|
Mouse   654 DVVLGLGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTA 718

  Fly   837 ASSTTT---------LAAPNPGPSLEEV----AKTIKREMIDADDSNEPLSSIRTAAVMLSTQTS 888
            |||.||         |..|:..|::..|    |:.|.|.:     |..|.|:::.||   :....
Mouse   719 ASSATTQVLFGNNIRLTVPSSVPTVNSVTPINARHIPRTL-----SAVPPSALKLAA---AANCQ 775

  Fly   889 VSELMDDEAEDDV 901
            ||::....:.|.|
Mouse   776 VSKVPSSSSVDSV 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(Pc)	NP_001260897.1	EPL1	7..139	CDD:287484	72/141 (51%)
Epc1	NP_081773.1	EPL1	7..148	CDD:287484	72/141 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..403		26/127 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..513		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..577		17/98 (17%)
		E_Pc_C	622..813	CDD:284226	33/175 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..813		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847195
Domainoid	1	1.000	156	1.000	Domainoid score	I4184
eggNOG	1	0.900	-	-		E1_KOG2261
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001287
OrthoInspector	1	1.000	-	-		otm43657
orthoMCL	1	0.900	-	-		OOG6_102490
Panther	1	1.100	-	-	LDO	PTHR14898
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R399
SonicParanoid	1	1.000	-	-		X1679
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730