DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prip and aqp4

DIOPT Version :9

Sequence 1:	NP_001246266.1	Gene:	Prip / 36237	FlyBaseID:	FBgn0033635	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001345242.1	Gene:	aqp4 / 445293	ZFINID:	ZDB-GENE-040724-152	Length:	346	Species:	Danio rerio

Alignment Length:	239	Identity:	92/239 - (38%)
Similarity:	129/239 - (53%)	Gaps:	17/239 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WQALIGEFLGNLILNFFACGACTQ---------IEDGTFKALAFGLAIFMAITIVGHLSGGHVNP 76
            |:|:.||||..:|....:.|:...         ..|....:|.|||:|...:...||:||.|:||
Zfish    36 WRAVSGEFLAMIIFVLLSLGSTINWGAKQENPPPADLVLISLCFGLSIATLVQCFGHISGAHINP 100

  Fly    77 AVTAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQDYYNGLGHTSLAPNITELQGLGIE 141
            |||..|:...::||.:..||::.|||||:.|.|.:..:.......|:|.||:...|:....:.||
Zfish   101 AVTVAMVATRKLSLAKGVFYLLAQCLGAVVGAAILYGVTPASVRGGMGVTSVNEEISAGHAIVIE 165

  Fly   142 FFLGLLLVLVVFGACDPHKPDSRYTAPLAIGMAVTLGHLGTIRYTGASMNPARTVGTAFATDIWA 206
            ..:...||..||..|||.:.|.:.:|.||||::|.:|||..|.||||||||||:.|.|.....|.
Zfish   166 LIITFELVFTVFATCDPKRNDLKGSAALAIGLSVCIGHLFAIPYTGASMNPARSFGPAVIMVKWQ 230

  Fly   207 SHWVYWVGPVLGGVAAALLYTQVLEAKPVPKVNEASEKYRTHAD 250
            .||||||||::||:.||.:|..:....|..|        |.:||
Zfish   231 DHWVYWVGPLIGGILAAAVYEYLFCPDPDLK--------RRYAD 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:294134	86/213 (40%)
aqp4	NP_001345242.1	MIP	32..250	CDD:278651	86/213 (40%)
aqp4	NP_001345242.1	DUF737	<290..>345	CDD:310129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2356
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.820