DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prip and AQP6

DIOPT Version :9

Sequence 1:	NP_001246266.1	Gene:	Prip / 36237	FlyBaseID:	FBgn0033635	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001643.2	Gene:	AQP6 / 363	HGNCID:	639	Length:	282	Species:	Homo sapiens

Alignment Length:	223	Identity:	86/223 - (38%)
Similarity:	116/223 - (52%)	Gaps:	16/223 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLW----QALIGEFLGNLILNFFACGAC----TQIEDGTFKALAFGLAIFMAITIVGHLSGGHVN 75
            |||    :||..|||...:..||..|:.    |.:......|:.|.|...||:.:....||.|.|
Human    18 RLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHAN 82

  Fly    76 PAVTAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQDYYNGLGHTSLAPNITELQGLGI 140
            ||||...||...|||.||..||..|.:||..|.|.:..::..|....||...:..:::..|.:.:
Human    83 PAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAV 147

  Fly   141 EFFLGLLLVLVVFGACDPHKPDSRYTA---PLAIGMAVTLGHLGTIRYTGASMNPARTVGTAFAT 202
            |..|.|.|||.||.:     .|||.|:   ...||::|.||||..|.:||.||||||:.|.|...
Human   148 ELLLTLQLVLCVFAS-----TDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIII 207

  Fly   203 DIWASHWVYWVGPVLGGVAAALLYTQVL 230
            ..:..|||:||||::|.:.|:|:|..||
Human   208 GKFTVHWVFWVGPLMGALLASLIYNFVL 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:294134	83/217 (38%)
AQP6	NP_001643.2	MIP	25..231	CDD:294134	80/210 (38%)
		NPA 1	82..84		1/1 (100%)
		NPA 2	196..198		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.030