Protein Alignment Prip and AQP5

DIOPT Version :10

• Sequence 1: NP_001246266.1
• Gene: Prip / 36237
• FlyBaseID: FBgn0033635
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_001642.1
• Gene: AQP5 / 362
• HGNCID: 638
• Length: 265
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 100/257 - (38%)
• Similarity: 139/257 - (54%)
• Gaps: 36/257 - (14%)

  Fly    22 QALIGEFLGNLILNFFACGAC----------TQIEDGTFKALAFGLAIFMAITIVGHLSGGHVNP 76
            :|:..|||..||..||..|:.          .||      ||||||||......:|.:||||:||
Human    12 KAVFAEFLATLIFVFFGLGSALKWPSALPTILQI------ALAFGLAIGTLAQALGPVSGGHINP 70

  Fly    77 AVTAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQDYYNGLGHTSLAPNITELQGLGIE 141
            |:|..:||..:|||:||||||..|.:|||||...:..:...:....|...:|..|.|:.|.:.:|
Human    71 AITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVE 135

  Fly   142 FFLGLLLVLVVFGACDPHKPDSRYTAP-----LAIGMAVTLGHLGTIRYTGASMNPARTVGTAFA 201
            ..|...|.|.:|.:     .|||.|:|     |:||::||||||..|.:||.||||||:.|.|..
Human   136 LILTFQLALCIFAS-----TDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVV 195

  Fly   202 TDIWA-SHWVYWVGPVLGGVAAALLYTQVL--------EAKPVPK-VNEASEKYRTHADERE 253
            .:.:: :|||:||||::|.|.||:||..:|        |...:.| ..|..|.:....:||:
Human   196 MNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERK 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:444743	91/219 (42%)
AQP5	NP_001642.1	MIP	4..221	CDD:395174	91/219 (42%)
		NPA 1. /evidence=ECO:0000305|PubMed:18768791, ECO:0000305|PubMed:26569106	69..71		1/1 (100%)
		NPA 2. /evidence=ECO:0000305|PubMed:18768791, ECO:0000305|PubMed:26569106	185..187		1/1 (100%)