Protein Alignment Prip and AQP4

DIOPT Version :9

• Sequence 1: NP_001246266.1
• Gene: Prip / 36237
• FlyBaseID: FBgn0033635
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_001304313.1
• Gene: AQP4 / 361
• HGNCID: 637
• Length: 352
• Species: Homo sapiens
• Alignment Length: 218
• Identity: 90/218 - (41%)
• Similarity: 123/218 - (56%)
• Gaps: 10/218 - (4%)

  Fly    21 WQALIGEFLGNLILNFFACGACTQIEDGTFK---------ALAFGLAIFMAITIVGHLSGGHVNP 76
            |:|:..|||..||....:.|: |....||.|         :|.|||:|...:...||:||||:||
Human    35 WKAVTAEFLAMLIFVLLSLGS-TINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINP 98

  Fly    77 AVTAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQDYYNGLGHTSLAPNITELQGLGIE 141
            |||..|:...:||:.::.||:..||||||.|...:.::.......|||.|.:..|:|...||.:|
Human    99 AVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVE 163

  Fly   142 FFLGLLLVLVVFGACDPHKPDSRYTAPLAIGMAVTLGHLGTIRYTGASMNPARTVGTAFATDIWA 206
            ..:...||..:|.:||..:.|...:..||||.:|.:|||..|.||||||||||:.|.|.....|.
Human   164 LIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWE 228

  Fly   207 SHWVYWVGPVLGGVAAALLYTQV 229
            :||:|||||::|.|.|..||..|
Human   229 NHWIYWVGPIIGAVLAGGLYEYV 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:294134	87/213 (41%)
AQP4	NP_001304313.1	MIP	31..248	CDD:278651	87/213 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.790