Protein Alignment Prip and AQP2

DIOPT Version :10

• Sequence 1: NP_001246266.1
• Gene: Prip / 36237
• FlyBaseID: FBgn0033635
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_000477.1
• Gene: AQP2 / 359
• HGNCID: 634
• Length: 271
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 101/275 - (36%)
• Similarity: 143/275 - (52%)
• Gaps: 34/275 - (12%)

  Fly    12 ELKSKELRLWQALIGEFLGNLILNFFACGAC----------TQIEDGTFKALAFGLAIFMAITIV 66
            ||:|  :...:|:..|||..|:..||..|:.          .||      |:||||.|...:..:
Human     3 ELRS--IAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQI------AMAFGLGIGTLVQAL 59

  Fly    67 GHLSGGHVNPAVTAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQDYYNGLGHTSLAPN 131
            ||:||.|:|||||...||...:|::||.|||..|.|||:||.|.:..:...|....|...:|:.:
Human    60 GHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNS 124

  Fly   132 ITELQGLGIEFFLGLLLVLVVFGACDPHKPDSRYTAPLAIGMAVTLGHLGTIRYTGASMNPARTV 196
            .|..|.:.:|.||.|.|||.:|.:.|..:.::..|..|:||.:|.||||..|.|||.||||||::
Human   125 TTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSL 189

  Fly   197 GTAFATDIWASHWVYWVGPVLGGVAAALLYTQVLEAKPVPKVNEASEKYR--------THADERE 253
            ..|..|..:..|||:|:||::|.:..:|||..||    .|.....||:..        |..:|||
Human   190 APAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVL----FPPAKSLSERLAVLKGLEPDTDWEERE 250

  Fly   254 GCKPN----HNPNHL 264
            ..:..    |:|..|
Human   251 VRRRQSVELHSPQSL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:444743	87/223 (39%)
AQP2	NP_000477.1	MIP	3..219	CDD:395174	87/223 (39%)
		NPA 1. /evidence=ECO:0000305|PubMed:24733887	68..70		1/1 (100%)
		NPA 2. /evidence=ECO:0000305|PubMed:24733887	184..186		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	248..271		6/18 (33%)