DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prip and AQP8

DIOPT Version :9

Sequence 1:	NP_001246266.1	Gene:	Prip / 36237	FlyBaseID:	FBgn0033635	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_011544124.1	Gene:	AQP8 / 343	HGNCID:	642	Length:	262	Species:	Homo sapiens

Alignment Length:	220	Identity:	79/220 - (35%)
Similarity:	113/220 - (51%)	Gaps:	21/220 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLWQALIGEFLGNLILNFFACGACTQIEDGT-----FKALAFGLAIFMAITIVGHLSGGHVNPAV 78
            |..|..:.|.||:.:..|..|  .:.||:||     ..|||.|||:.:.|..:|::||||.||||
Human    34 RFVQPCLVELLGSALFIFIGC--LSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAV 96

  Fly    79 TAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQD-YYNGLGHTSLAPNIT-ELQG---- 137
            :...::.|.::|:....|.|.|.||.:.|.|..|.:..:: ::|..|    |..:| :.||
Human    97 SLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASG----AAFVTVQEQGQVAG 157

  Fly   138 -LGIEFFLGLLLVLVV-FGACDPHKPDSRYTAPLAIGMAVTLGHLGTIRYTGASMNPARTVGTAF 200
             |..|..|..||.|.| .||.  ::......||.:||.|||:..|.....:|..|||||..|.|.
Human   158 ALVAEIILTTLLALAVCMGAI--NEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAV 220

  Fly   201 ATDIWASHWVYWVGPVLGGVAAALL 225
            ..:.|..||:||:||:|.|:...||
Human   221 VANHWNFHWIYWLGPLLAGLLVGLL 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:294134	79/220 (36%)
AQP8	XP_011544124.1	MIP	39..232	CDD:294134	69/200 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2356
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760