DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prip and Aqp8

DIOPT Version :9

Sequence 1:	NP_001246266.1	Gene:	Prip / 36237	FlyBaseID:	FBgn0033635	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_062031.1	Gene:	Aqp8 / 29172	RGDID:	2146	Length:	263	Species:	Rattus norvegicus

Alignment Length:	239	Identity:	77/239 - (32%)
Similarity:	116/239 - (48%)	Gaps:	22/239 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SLGLNELKSKELRL--------W-----QALIGEFLGNLILNFFACGACTQIEDGT---FKALAF 55
            |:.|.|:|.||..:        |     |..:.|.||:.:..|..|.:..:....|   ..|||.
  Rat    10 SMDLREIKGKETNMADSYHGMSWYEQYIQPCVVELLGSALFIFIGCLSVIENSPNTGLLQPALAH 74

  Fly    56 GLAIFMAITIVGHLSGGHVNPAVTAGMLVAGRISLIRAFFYVVFQCLGAIAGTAAVKILIDQD-Y 119
            |||:.:.|..:|::||||.||||:..:.:.|.:..:....|.|.|..|.:.|.|..|::..:: :
  Rat    75 GLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPYWVSQLFGGMIGAALAKVVSPEERF 139

  Fly   120 YNGLGHTSLAPNITE--LQGLGIEFFLGLLLVLVV-FGACDPHKPDSRYTAPLAIGMAVTLGHLG 181
            :|..|.........|  .:.||:|..:.:||||.| .||.  ::......||.:||.:|.:..|.
  Rat   140 WNASGAAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAV--NEKTMGPLAPFSIGFSVIVDILA 202

  Fly   182 TIRYTGASMNPARTVGTAFATDIWASHWVYWVGPVLGGVAAALL 225
            ....:||.|||||..|.|.....|..||:||:||:|.|:...||
  Rat   203 GGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLL 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prip	NP_001246266.1	MIP	12..226	CDD:294134	75/234 (32%)
Aqp8	NP_062031.1	MIP	40..250	CDD:294134	69/209 (33%)
		NPA 1	94..96		1/1 (100%)
		NPA 2	212..214		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730