DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drip and aqp4

DIOPT Version :9

Sequence 1:	NP_001260893.1	Gene:	Drip / 36236	FlyBaseID:	FBgn0015872	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001345242.1	Gene:	aqp4 / 445293	ZFINID:	ZDB-GENE-040724-152	Length:	346	Species:	Danio rerio

Alignment Length:	255	Identity:	107/255 - (41%)
Similarity:	152/255 - (59%)	Gaps:	24/255 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MSKFVGVADITENKKIWRMLLGELVGTFFLIFVGVGSTTSGSVPQ----------IAFTFGLTVA 61
            |:.|.||    ..::.||.:.||.:.....:.:.:|||.:....|          |:..|||::|
Zfish    24 MAAFKGV----WTQEFWRAVSGEFLAMIIFVLLSLGSTINWGAKQENPPPADLVLISLCFGLSIA 84

  Fly    62 TIAQGLGHLSGCHINPAVTLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGV 126
            |:.|..||:||.|||||||:..:...::|:.|..||::.||:||:.|||::.........|.:||
Zfish    85 TLVQCFGHISGAHINPAVTVAMVATRKLSLAKGVFYLLAQCLGAVVGAAILYGVTPASVRGGMGV 149

  Fly   127 SSFDPSLNCAQAVLIEALITFILVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASM 191
            :|.:..::...|::||.:|||.|||.|.|..||.|.|:||||.||:||::..|||.||..:||||
Zfish   150 TSVNEEISAGHAIVIELIITFELVFTVFATCDPKRNDLKGSAALAIGLSVCIGHLFAIPYTGASM 214

  Fly   192 NPARSFGPAVVQGVWTYHWVYWVGPIAGGLLAGIIYRLIF----KLKK------GCTPFQ 241
            ||||||||||:...|..||||||||:.||:||..:|..:|    .||:      ..:|||
Zfish   215 NPARSFGPAVIMVKWQDHWVYWVGPLIGGILAAAVYEYLFCPDPDLKRRYADVLSKSPFQ 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drip	NP_001260893.1	MIP	23..227	CDD:294134	96/213 (45%)
aqp4	NP_001345242.1	MIP	32..250	CDD:278651	96/217 (44%)
aqp4	NP_001345242.1	DUF737	<290..>345	CDD:310129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2854
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37507
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3663
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	1	1.000	-	-		otm25039
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	1	1.100	-	-	LDO	PTHR19139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2356
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870