DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drip and AQP6

DIOPT Version :9

Sequence 1:	NP_001260893.1	Gene:	Drip / 36236	FlyBaseID:	FBgn0015872	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001643.2	Gene:	AQP6 / 363	HGNCID:	639	Length:	282	Species:	Homo sapiens

Alignment Length:	220	Identity:	100/220 - (45%)
Similarity:	126/220 - (57%)	Gaps:	15/220 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KKIWRMLLGELVGTFFLIFVGVGS-----TTSGSVPQIAFTFGLTVATIAQGLGHLSGCHINPAV 79
            |.|.|.|..|.:.|...:|.||||     |...||.|||.||.|..|...|.....||.|.||||
Human    21 KAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAV 85

  Fly    80 TLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGD----LGVSSFDPSLNCAQAVL 140
            ||.||:...||:.:|..|:..|.|||..|||:    |.||..||    ||::....|::..|||.
Human    86 TLAFLVGSHISLPRAVAYVAAQLVGATVGAAL----LYGVMPGDIRETLGINVVRNSVSTGQAVA 146

  Fly   141 IEALITFILVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASMNPARSFGPAVVQGV 205
            :|.|:|..||..|.|.:| .|| ..||....:|:::|.|||..|..:|.|||||||||||::.|.
Human   147 VELLLTLQLVLCVFASTD-SRQ-TSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGK 209

  Fly   206 WTYHWVYWVGPIAGGLLAGIIYRLI 230
            :|.|||:||||:.|.|||.:||..:
Human   210 FTVHWVFWVGPLMGALLASLIYNFV 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drip	NP_001260893.1	MIP	23..227	CDD:294134	96/212 (45%)
AQP6	NP_001643.2	MIP	25..231	CDD:294134	96/211 (45%)
		NPA 1	82..84		1/1 (100%)
		NPA 2	196..198		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960