Protein Alignment Drip and AQP5

DIOPT Version :9

• Sequence 1: NP_001260893.1
• Gene: Drip / 36236
• FlyBaseID: FBgn0015872
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_001642.1
• Gene: AQP5 / 362
• HGNCID: 638
• Length: 265
• Species: Homo sapiens
• Alignment Length: 210
• Identity: 91/210 - (43%)
• Similarity: 131/210 - (62%)
• Gaps: 6/210 - (2%)

  Fly    24 RMLLGELVGTFFLIFVGVGSTTS--GSVP---QIAFTFGLTVATIAQGLGHLSGCHINPAVTLGF 83
            :.:..|.:.|...:|.|:||...  .::|   |||..|||.:.|:||.||.:||.|||||:||..
Human    12 KAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLAL 76

  Fly    84 LIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGVSSFDPSLNCAQAVLIEALITFI 148
            |:..:||:|:|.||:..|.|||||||.::.......|.|:|.|::.:.:....||:::|.::||.
Human    77 LVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQ 141

  Fly   149 LVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASMNPARSFGPAVVQGVWT-YHWVY 212
            |...:.|.:|..|....||..|::||::..|||..|..:|.|||||||||||||...:: .|||:
Human   142 LALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVF 206

  Fly   213 WVGPIAGGLLAGIIY 227
            |||||.|.:||.|:|
Human   207 WVGPIVGAVLAAILY 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drip	NP_001260893.1	MIP	23..227	CDD:294134	90/208 (43%)
AQP5	NP_001642.1	MIP	4..221	CDD:395174	90/208 (43%)
		NPA 1. /evidence=ECO:0000305|PubMed:18768791, ECO:0000305|PubMed:26569106	69..71		1/1 (100%)
		NPA 2. /evidence=ECO:0000305|PubMed:18768791, ECO:0000305|PubMed:26569106	185..187		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140770
Domainoid	1	1.000	190	1.000	Domainoid score	I3263
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3838
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	1	1.000	-	-		otm41396
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910