DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drip and AQP4

DIOPT Version :9

Sequence 1:	NP_001260893.1	Gene:	Drip / 36236	FlyBaseID:	FBgn0015872	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001304313.1	Gene:	AQP4 / 361	HGNCID:	637	Length:	352	Species:	Homo sapiens

Alignment Length:	234	Identity:	101/234 - (43%)
Similarity:	138/234 - (58%)	Gaps:	13/234 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MSKFVGVADITENKKIWRMLLGELVGTFFLIFVGVGST-----TSGSVP----QIAFTFGLTVAT 62
            |..|.||    ..:..|:.:..|.:.....:.:.:|||     |...:|    .|:..|||::||
Human    23 MVAFKGV----WTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIAT 83

  Fly    63 IAQGLGHLSGCHINPAVTLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGVS 127
            :.|..||:||.|||||||:..:...:|||.|:.|||..||:|||.||.::.:.......|.|||:
Human    84 MVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVT 148

  Fly   128 SFDPSLNCAQAVLIEALITFILVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASMN 192
            ....:|.....:|:|.:|||.|||.:.|..|..|.|:.||..||:|.::|.|||.||..:|||||
Human   149 MVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMN 213

  Fly   193 PARSFGPAVVQGVWTYHWVYWVGPIAGGLLAGIIYRLIF 231
            |||||||||:.|.|..||:||||||.|.:|||.:|..:|
Human   214 PARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drip	NP_001260893.1	MIP	23..227	CDD:294134	95/212 (45%)
AQP4	NP_001304313.1	MIP	31..248	CDD:278651	95/216 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3263
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37507
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3838
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	1	1.000	-	-		otm41396
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	1	1.100	-	-	LDO	PTHR19139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840