DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drip and Aqp4

DIOPT Version :9

Sequence 1:	NP_001260893.1	Gene:	Drip / 36236	FlyBaseID:	FBgn0015872	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001304658.1	Gene:	Aqp4 / 11829	MGIID:	107387	Length:	352	Species:	Mus musculus

Alignment Length:	242	Identity:	107/242 - (44%)
Similarity:	147/242 - (60%)	Gaps:	17/242 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MSKFVGVADITENKKIWRMLLGELVGTFFLIFVGVGSTTS--GS-------VPQIAFTFGLTVAT 62
            |..|.||    ..:..|:.:..|.:.|...:.:|||||.:  ||       :..|:..|||::||
Mouse    23 MVAFKGV----WTQAFWKAVSAEFLATLIFVLLGVGSTINWGGSENPLPVDMVLISLCFGLSIAT 83

  Fly    63 IAQGLGHLSGCHINPAVTLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGVS 127
            :.|..||:||.|||||||:..:...:|||.|:.||||.||:|||.||.::.:.......|.|||:
Mouse    84 MVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVT 148

  Fly   128 SFDPSLNCAQAVLIEALITFILVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASMN 192
            :...:|.....:|:|.:|||.|||.:.|..|..|.|:.||..||:|.::|.|||.||..:|||||
Mouse   149 TVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMN 213

  Fly   193 PARSFGPAVVQGVWTYHWVYWVGPIAGGLLAGIIYRLIF----KLKK 235
            |||||||||:.|.|..||:||||||.|.:|||.:|..:|    :||:
Mouse   214 PARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKR 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drip	NP_001260893.1	MIP	23..227	CDD:294134	99/212 (47%)
Aqp4	NP_001304658.1	MIP	31..248	CDD:278651	99/216 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3056
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37507
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3747
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53729
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	1	1.000	-	-		FOG0000054
OrthoInspector	1	1.000	-	-		otm43450
orthoMCL	1	0.900	-	-		OOG6_100198
Panther	1	1.100	-	-	LDO	PTHR19139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2356
SonicParanoid	1	1.000	-	-		X83
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870