DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7763 and PKD1

DIOPT Version :9

Sequence 1:	NP_001356891.1	Gene:	CG7763 / 36235	FlyBaseID:	FBgn0040503	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	XP_024306066.1	Gene:	PKD1 / 5310	HGNCID:	9008	Length:	4343	Species:	Homo sapiens

Alignment Length:	198	Identity:	47/198 - (23%)
Similarity:	77/198 - (38%)	Gaps:	39/198 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RVEACEAAVAIA--RIALNDRRLDNFGTSTNLQLENQNTS-----QQLLTHGTAMGRKL-----E 104
            :|||..||:.:.  ....:|..||       |.::|:..|     ..::..|....|.:     .
Human   351 QVEAAPAALELVCPSSVQSDESLD-------LSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPS 408

  Fly   105 ENEIFQQLGSKYYYIEKEEKLNWHDALDKCHKMGGHLASLQSQEELDRFNNQLNGLNRYWIDVTN 169
            :.|||.  |:.:.|....||..|..|.::|....|...::.....:.||  .::.:.|. :||..
Human   409 DTEIFP--GNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRF--LVSRVTRS-LDVWI 468

  Fly   170 QFNESEFVSVTKGSKANFLS------WADGEP---TKDGECVDIRTFNGKT-TMNDNSCFANLYF 224
            .|:..:.|.|....:....|      |..|||   |.: .||.:    |.| ..|.:.|.|...:
Human   469 GFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAE-HCVRL----GPTGWCNTDLCSAPHSY 528

  Fly   225 ICE 227
            :||
Human   529 VCE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7763	NP_001356891.1	CLECT	116..228	CDD:153057	30/122 (25%)
PKD1	XP_024306066.1	LRR	<50..>126	CDD:227223
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2768	CDD:188093	47/198 (24%)
		leucine-rich repeat	117..129	CDD:275378
		GPS	3051..3100	CDD:197639
		PLAT_polycystin	3158..3277	CDD:238850
		PKD_channel	3751..4153	CDD:332708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910