DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7763 and Pkd1

DIOPT Version :9

Sequence 1:	NP_001356891.1	Gene:	CG7763 / 36235	FlyBaseID:	FBgn0040503	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	XP_036016298.1	Gene:	Pkd1 / 18763	MGIID:	97603	Length:	4316	Species:	Mus musculus

Alignment Length:	371	Identity:	60/371 - (16%)
Similarity:	95/371 - (25%)	Gaps:	179/371 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CLSSSYSAAC---------EGVESDSQCAAYCYGV---------LNPCIASMGNLQRRVEACEAA 59
            ||..:.|.|.         ||......|:|:|:..         .|.|:...|.......||.:.
Mouse   183 CLPDNSSGAVAAVPFYFAHEGPLETEACSAFCFSAGEGLAALSEQNQCLCGAGQASNSSAACSSW 247

  Fly    60 VAIARIALN----------------------------------DRRLD----------NFG---- 76
            .:...::||                                  |..:.          |||
Mouse   248 CSSISLSLNSACGGPTLLQHTFPASPGATLVGPHGPLASGQPADFHITSSLPISSTRWNFGDGSP 312

  Fly    77 ---------------------------------TSTNLQLENQNTSQQLL----THGTAM----- 99
                                             ..|.:|:|...|..:|:    .|....
Mouse   313 EVDMASPAATHFYVLPGSYHMTVVLALGAGSALLETEVQVEATPTVLELVCPSFVHSNESLELGI 377

  Fly   100 ----GRKLE----------------------ENEIFQQLGSKYYYIEKEEKLNWHDALDKCHKMG 138
                |..||                      :.|||.  |:.:.|....||..|..|.::|....
Mouse   378 RHRGGSALEVTYSILALDKEPAQVVHPLCPLDTEIFP--GNGHCYRLVAEKAPWLQAQEQCRTWA 440

  Fly   139 GHLASLQSQEELDRFNNQLNGLNR---YWIDVTNQFNESEFVSVTKG--------SKANFLSWAD 192
            |...::.....:..|  .::.:.|   .||..::       |..|:|        |..:..:|..
Mouse   441 GAALAMVDSPAIQHF--LVSKVTRSLDVWIGFSS-------VEGTEGLDPRGEAFSLESCQNWLP 496

  Fly   193 GEP---TKD--------GECVDIRTFNGKTTMNDNSCFANLYFICE 227
            |||   |.:        |:|            |.:.|.|...::||
Mouse   497 GEPHPATAEHCVRLGPAGQC------------NTDLCSAPHSYVCE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7763	NP_001356891.1	CLECT	116..228	CDD:153057	27/134 (20%)
Pkd1	XP_036016298.1	LRRNT	32..71	CDD:214470
		LRR_8	61..127	CDD:404697
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2731	CDD:188093	60/371 (16%)
		leucine-rich repeat	117..129	CDD:275378
		GPS	3011..3060	CDD:413374
		PLAT_polycystin	3118..3237	CDD:238850
		PKD_channel	3726..4126	CDD:400395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910