DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7763 and NCAN

DIOPT Version :9

Sequence 1:	NP_001356891.1	Gene:	CG7763 / 36235	FlyBaseID:	FBgn0040503	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_004377.2	Gene:	NCAN / 1463	HGNCID:	2465	Length:	1321	Species:	Homo sapiens

Alignment Length:	234	Identity:	58/234 - (24%)
Similarity:	86/234 - (36%)	Gaps:	32/234 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLCLSSSYSAACEGVESDSQCAAYCYGVLNPCI-ASMGNLQRRVEACEAAVAIA----RIALND- 69
            |....:..:|..|.|.||.     |..  |||: ....|....:..|......|    .|.::|
Human   993 PALPGTPMNAGAEEVHSDP-----CEN--NPCLHGGTCNANGTMYGCSCDQGFAGENCEIDIDDC 1050

  Fly    70 --RRLDNFGTSTNLQLENQNTSQQLLTHGTAMGRKLEEN-----EIFQQLGSKYYYIEKEEKLNW 127
              ...:|.||.  :...|......|.::|.:...|..|.     ..||  |..|.|.  ..:..|
Human  1051 LCSPCENGGTC--IDEVNGFVCLCLPSYGGSFCEKDTEGCDRGWHKFQ--GHCYRYF--AHRRAW 1109

  Fly   128 HDALDKCHKMGGHLASLQSQEELDRFNNQLNGLNRYWIDVTNQFNESEFVSVTKGSKANFLSWAD 192
            .||...|.:..|||.|:.|.||....|:  .|....||.:.::..|.:| ..|..:...|.:|.:
Human  1110 EDAEKDCRRRSGHLTSVHSPEEHSFINS--FGHENTWIGLNDRIVERDF-QWTDNTGLQFENWRE 1171

  Fly   193 GEPTK---DGECVDIRTFNGKTTMNDNSCFANLYFICEK 228
            .:|..   .||...:...:.....||..|..||.::|:|
Human  1172 NQPDNFFAGGEDCVVMVAHESGRWNDVPCNYNLPYVCKK 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7763	NP_001356891.1	CLECT	116..228	CDD:153057	31/114 (27%)
NCAN	NP_004377.2	Ig_Neurocan	51..161	CDD:143310
		Link_domain_CSPGs_modules_1_3	160..254	CDD:239594
		Link_domain_CSPGs_modules_2_4	261..356	CDD:239597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..414
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..579
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..731
		O-glycosylated at one site	708..712
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..844
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..955
		EGF	1012..1042	CDD:278437	7/31 (23%)
		EGF_CA	1046..1082	CDD:238011	7/37 (19%)
		CLECT	1088..1211	CDD:295302	35/130 (27%)
		CCP	1215..1271	CDD:153056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1275..1321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910