DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7763 and CLEC4M

DIOPT Version :9

Sequence 1:	NP_001356891.1	Gene:	CG7763 / 36235	FlyBaseID:	FBgn0040503	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_055072.3	Gene:	CLEC4M / 10332	HGNCID:	13523	Length:	399	Species:	Homo sapiens

Alignment Length:	218	Identity:	51/218 - (23%)
Similarity:	93/218 - (42%)	Gaps:	33/218 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 YGVLNPCIASMGNLQRR-------VEACEAAVAIARIALNDRRLDNFGTSTNL-----QLENQNT 88
            |..|....|::|.|..:       .|..|...|:..:....:..:.:...|.|     :|.:|:.
Human   182 YQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPEKSKLQEIYQELTQLKAAVGELPDQSK 246

  Fly    89 SQQLLTHGTAMGRKLE--------ENEIFQQLGSKYYYIEKEEKLNWHDALDKCHKMGGHLASLQ 145
            .||:....|.:....|        :...||   ...|::...:: ||||::..|.::...|..::
Human   247 QQQIYQELTDLKTAFERLCRHCPKDWTFFQ---GNCYFMSNSQR-NWHDSVTACQEVRAQLVVIK 307

  Fly   146 SQEELDRFNNQLNGLNRY-WIDVT--NQFNESEFVSVTKGSKANFLSWADGEPTKDG--ECVDIR 205
            :.||.:....|.:..||: |:.::  ||....::|..:..|.:....|..|||...|  :|.:
Human   308 TAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSGNEDCAE-- 370

  Fly   206 TFNGKTTMNDNSCFANLYFICEK 228
             |:| :..|||.|..:.|:||:|
Human   371 -FSG-SGWNDNRCDVDNYWICKK 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7763	NP_001356891.1	CLECT	116..228	CDD:153057	32/116 (28%)
CLEC4M	NP_055072.3	Endocytosis signal. /evidence=ECO:0000250	14..15
		transmembrane domain	44..71
		7 X approximate tandem repeats	108..269		16/86 (19%)
		DUF342	<140..251	CDD:302792	14/68 (21%)
		CLECT_DC-SIGN_like	268..391	CDD:153060	34/130 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010