DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-3 and TPR9

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001321056.1	Gene:	TPR9 / 840233	AraportID:	AT1G33400	Length:	810	Species:	Arabidopsis thaliana

Alignment Length:	632	Identity:	144/632 - (22%)
Similarity:	247/632 - (39%)	Gaps:	156/632 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FAEYYLKLKDQAGPNCES---DIAKLSACKSDEERVAYVEKLPWVQAGDANLVVNQEF--AGKNA 71
            :..|||:|      |..|   .:..||...|:                    :.|.|.  .|||.
plant    34 YLRYYLQL------NFSSLSFSLVLLSQAVSE--------------------LANPELGCCGKNE 72

  Fly    72 SLAAEIKERATSAFKAKKWLEAMMLYTRSYVALPSENVAEIRVVLA----NRSATLYHMQKYQEC 132
            ..:.::|.|....|:::.:.||:.||:::....|.:.:...:.:||    ||:..|:::...:|.
plant    73 ETSLDLKRRGNHCFRSRDFDEALRLYSKALRVAPLDAIDGDKSLLASLFLNRANVLHNLGLLKES 137

  Fly   133 LIDIKRALDLSYSKDLIY-KLYERQARCYMALKDYPHTIDSFKKCITAMD-DSTLASDKRAKLNL 195
            |.|..|||.:    |..| |.:.|:.:....|.:|.   |:|:....:|. :|:|...|:.:..|
plant   138 LRDCHRALRI----DPYYAKAWYRRGKLNTLLGNYK---DAFRDITVSMSLESSLVGKKQLQNEL 195

  Fly   196 DAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENEFVSPLVRIDSNRQEGRFARASADVK 260
            .|   |...||: :|.:.:..:......:|....|::|.:     :|..|.:::||...:..|::
plant   196 KA---IPDYQNN-QTLEHDEYRPSNDAGVDHLPSVQMEVK-----LRCVSTKEKGRGMVSECDIE 251

  Fly   261 PGEELLVERPFVSVLLEKFAKTHCENCFMRTVVP---VACPRCADVLYCSEQCR---------EE 313
            ....:.||.||..|:.:...:|||..|.  ..:|   |.||.|:..:||||.|:         .|
plant   252 EASVIHVEEPFSVVISKSCRETHCHFCL--NELPADTVPCPSCSIPVYCSESCQIQSGGMLSTNE 314

  Fly   314 ASKKY-------------------------------HKYEC--GIVPIIWRSGASINNHIALRII 345
            ..|.:                               |::||  ...|.:..|.|.:...|.:::|
plant   315 MDKHHIFQKLPDDIVEHIKGVTSADIYYFATDLIQEHQHECRGANWPAVLPSDAVLAGRIIMKLI 379

  Fly   346 ASKPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLR 410
            ...        |...|            ..:.:.:.:|.....:..|.|..:..|::..|..||.
plant   380 NQG--------KAATD------------LSNLQEILELSHTYSKMNPENKLELHLLSIVLIWCLS 424

  Fly   411 AGGYFGSEPKPD--EVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGRE---------------- 457
            .    .|.|...  |.|:..:::|  |..|:.|:..||   :..|||..
plant   425 K----SSCPNLSVCEASVTQTIIL--LSQIKVNSIAVA---RMKSSGDSFKCLPSGNISTKEPIQ 480

  Fly   458 --KSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERSER 520
              :.|.:|.|:|.|.:||||||.|.:..||....:.:.:...:..|.|:..:|||...:.:...|
plant   481 SLEQIRVGQALYKTGSLFNHSCKPNIHLYFLSRGLIMQTTEFVPTGCPLELSYGPEVGKWDCKNR 545

  Fly   521 QARLKDLYWFECSCDACIDNWPKFDDLPRDVIR-FRCDAPNNCSAVI 566
            ...|::.|:|.|.|..|..  ....||   ||. :.| ...||:.|:
plant   546 IRFLEEEYFFHCRCRGCAQ--INISDL---VINGYGC-VNTNCTGVV 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150	19/72 (26%)
		TPR repeat	74..103	CDD:276809	7/28 (25%)
		TPR repeat	108..142	CDD:276809	11/37 (30%)
		TPR repeat	150..177	CDD:276809	7/27 (26%)
		zf-MYND	284..323	CDD:280009	15/81 (19%)
TPR9	NP_001321056.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	61	1.000	Domainoid score	I3824
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I2036
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	1	1.000	-	-		FOG0007629
OrthoInspector	1	1.000	-	-		otm3360
orthoMCL	1	0.900	-	-		OOG6_112258
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770