Protein Alignment Smyd4-3 and smyd4

DIOPT Version :10

• Sequence 1: NP_725048.1
• Gene: Smyd4-3 / 36234
• FlyBaseID: FBgn0033633
• Length: 660
• Species: Drosophila melanogaster
• Sequence 2: NP_001070062.1
• Gene: smyd4 / 767654
• ZFINID: ZDB-GENE-060929-248
• Length: 753
• Species: Danio rerio
• Alignment Length: 699
• Identity: 153/699 - (21%)
• Similarity: 257/699 - (36%)
• Gaps: 217/699 - (31%)

  Fly    57 DANLV--VNQEFA-GKNASLAAEIKERATSAFKAKKWLEAMMLYTRSYVALPSENVAEIRVVLAN 118
            |.|::  ::::|: .|:...|:|.:::...:||.|.:..|::.|::. |....:|..|:.:..||
Zfish    48 DLNILSRISEKFSVKKSPETASEFRQQGNLSFKVKDYPAAVLHYSKG-VCHADKNTDELSLCYAN 111

  Fly   119 RSATLYHMQKYQECLIDIKRALDLSYSKDLIYKLYERQARCYMALK-----DYPHTIDSFKKCIT 178
            |||.|::...||.||.||:|:|:..|...|..||..||..|...|:     :.|||......|..
Zfish   112 RSAALFYQGLYQACLEDIRRSLEAGYPSHLQDKLQTRQTACQNQLRKAEKPNIPHTDHQLSPCQK 176

  Fly   179 AMDDSTLASDKRAKLNLDAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENEFVSPLVRI 243
            .::.:...||.                                                   |.:
Zfish   177 TVNSTGHLSDG---------------------------------------------------VSV 190

  Fly   244 DSNRQEGRFARASADVKPGEELLVERPFVSVLL---------EKFAKT------HCENCFMRTVV 293
            ..:..:||......:...||.:|.:..:.|||:         .|..:|      ||.:|..:::.
Zfish   191 YFSSDKGRHMLVMENKPAGEVVLEDEAYCSVLIPANIFNTGTNKAVETFGTEDRHCHHCLSQSLS 255

  Fly   294 PVACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRII-ASKPLDYFLKLK 357
            .|.||:|:...||.|.|:::|..::|::||.:...:...|  :..|:|||:: .:...:..:.:|
Zfish   256 FVPCPKCSYARYCGESCQKDAWDQWHQWECPVGADLLAIG--VLGHLALRVVLKAGQTEVQMGIK 318

  Fly   358 PTIDEELT-----PEQLISLPKD--------------DFRRVAQLERHQGERQPSNFFQHVLMAR 403
            .|.|...|     |.|| ||..|              .:..:..|..|..:..|::.|...:...
Zfish   319 NTKDHVTTYKNDSPVQL-SLGGDCGKSLDHTDCFHGSSYMGIYSLLPHVAQHSPASRFLMAITMA 382

  Fly   404 FLTNCLRAGGYFGSEPKPD----------------EVSIICSLVLRSLQFIQFNTHEVAELHKFS 452
            .:...|:.|      |.|:                |:|::.:..||.:..::.|...:..:....
Zfish   383 VIYGKLQGG------PPPNKWMSFKDEGVKASWQPEMSMLGATALRHMMQLRCNAQAITAVRVKE 441

  Fly   453 SSG----REKSIFIGGAIYPTLALFNHSCDPGVVRYF--------------------------RG 487
            .||    ....|.|..||:|.|:|.||||.|.....|                          .|
Zfish   442 ESGMAVQSSSEIRIATAIFPVLSLLNHSCSPNTSISFTTGFQPDPHNQLGCSEGHFDHPKGSRSG 506

  Fly   488 TTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDACIDNWPKFDDLPRDVI 552
            .|:.:.:.:.:.||..|...|||..::.|..|||..|.:.|:|:|.|.||          .||:.
Zfish   507 VTVTVRASKDLTAGQEILHCYGPHRSRMEVKERQRLLLEQYFFQCVCQAC----------QRDLS 561

  Fly   553 RFRCDAPNNCSAVIEVPPSCNDFMVKCVTCG------------------------EITNILKGLK 593
            .   .:||   |.....|.     :|||.||                        ::.|.|:|.:
Zfish   562 E---GSPN---AKEHTAPG-----MKCVKCGKPLQSHTDGYTCSWSSCGHQISSADVQNRLQGFQ 615

  Fly   594 VMQDTEMMTRTAKRLYET----------------------GEYPKALAK 620
            ::.|..:......||.|.                      ||...|||:
Zfish   616 LLLDEAVHLMEQDRLNEALHILQSAFSQANSILTETHPFQGELADALAR 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR repeat	74..103	CDD:276809	7/28 (25%)
		TPR repeat	108..142	CDD:276809	16/33 (48%)
		TPR repeat	150..177	CDD:276809	9/31 (29%)
		SET_SMYD4	235..537	CDD:380934	86/382 (23%)
		zf-MYND	284..323	CDD:460312	12/38 (32%)
smyd4	NP_001070062.1	NlpI	<65..>134	CDD:443815	23/69 (33%)
		TPR repeat	68..96	CDD:276809	7/28 (25%)
		TPR repeat	101..134	CDD:276809	15/32 (47%)
		zf-MYND	246..285	CDD:460312	12/38 (32%)
		SET_SMYD4	<352..556	CDD:380934	45/209 (22%)
		TPR_12	621..683	CDD:315987	8/44 (18%)