DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smyd4-3 and SMYD3

DIOPT Version :10

Sequence 1:NP_725048.1 Gene:Smyd4-3 / 36234 FlyBaseID:FBgn0033633 Length:660 Species:Drosophila melanogaster
Sequence 2:NP_001161212.1 Gene:SMYD3 / 64754 HGNCID:15513 Length:428 Species:Homo sapiens


Alignment Length:494 Identity:98/494 - (19%)
Similarity:172/494 - (34%) Gaps:138/494 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 KPVKLENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTV 292
            :|:|:| :|        :..:.|...||...::|||.|....|....:.:......|:.|.:...
Human     2 EPLKVE-KF--------ATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKE 57

  Fly   293 VPVACPRCADVLYCSEQCREEASKKYHKYECGIV----PIIWRSGASINNHIALRIIASKP---- 349
            ..:.|.:|....|||.:|:::|... ||.||..:    |........:...:..:::...|    
Human    58 KLMRCSQCRVAKYCSAKCQKKAWPD-HKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESE 121

  Fly   350 -LDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRAGG 413
             |..|..|:..|: :||.                 ::.:|.||....|||     |:...::...
Human   122 KLYSFYDLESNIN-KLTE-----------------DKKEGLRQLVMTFQH-----FMREEIQDAS 163

  Fly   414 YFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCD 478
            ..  .|..|.......::..|.........||                 |..:||:::|.|||||
Human   164 QL--PPAFDLFEAFAKVICNSFTICNAEMQEV-----------------GVGLYPSISLLNHSCD 209

  Fly   479 PGVVRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERSERQARLKDLYWFECSCDACIDN--- 540
            |.....|.|..:.:.:||.||.|..:...|..|....|  ||:.:|:|.|.|||.|..|...   
Human   210 PNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSE--ERRKQLRDQYCFECDCFRCQTQDKD 272

  Fly   541 ----------WPKFDDLPRDVIRFRC-----DAPNNCSAVI----EVPPSCNDFMVK-------- 578
                      |.:..:..:.:...:.     .....|.|:|    |..|..|.:.:|        
Human   273 ADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDA 337

  Fly   579 CVTCGEITNIL--------------------KGLKVMQDTEMMTRTAKRLYETGEYPKALAKFVD 623
            |:..|.:...|                    :|::||       :..|.....|.:|:|:..   
Human   338 CINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVM-------KVGKLQLHQGMFPQAMKN--- 392

  Fly   624 LIRIMYEVLAPPFPDFCESQQH---------LKDCFLNL 653
             :|:.::::.     ....::|         |::|..|:
Human   393 -LRLAFDIMR-----VTHGREHSLIEDLILLLEECDANI 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smyd4-3NP_725048.1 TPR repeat 74..103 CDD:276809
TPR repeat 108..142 CDD:276809
TPR repeat 150..177 CDD:276809
SET_SMYD4 235..537 CDD:380934 71/310 (23%)
zf-MYND 284..323 CDD:460312 11/38 (29%)
SMYD3NP_001161212.1 SET_SMYD3 5..268 CDD:380980 74/316 (23%)
zf-MYND 49..87 CDD:460312 11/38 (29%)
C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000269|PubMed:25738358 272..428 23/170 (14%)
Blue background indicates that the domain is not in the aligned region.

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