DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-3 and smyd3

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001032477.1	Gene:	smyd3 / 569507	ZFINID:	ZDB-GENE-051120-138	Length:	380	Species:	Danio rerio

Alignment Length:	355	Identity:	77/355 - (21%)
Similarity:	119/355 - (33%)	Gaps:	130/355 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 EGRFARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPVACPRCADVLYCSEQCREE 313
            :|...||..::||||.:....||...:...|.||.|::|..|......|.:|....||:.||:::
Zfish    14 KGNGLRALREIKPGEVIYSCEPFAFCVARDFLKTACQSCLKRGESLSRCSQCKTARYCNVQCQKQ 78

  Fly   314 ASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTIDEELTPE---QLISLPKD 375
            |... ||.||..:           .|:..||             ||....|...   :|:|..:.
Zfish    79 AWPD-HKRECKCL-----------KHLQPRI-------------PTDSVRLVARIIFKLLSQSES 118

  Fly   376 DFRRVAQLERHQG-------------------------------ERQPSNFFQHVLMARFLTNCL 409
            |...:..:..||.                               .|.||......|:||...||
Zfish   119 DQEELYSIAEHQSHLADMSEEKTEGLKHLCTTLQVYLAEENCDLSRLPSGLDPVSLLARVTCNC- 182

  Fly   410 RAGGYFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFS-SSGREKSIFIGGAIYPTLALF 473
                                                     || |.|..:.:.:|  :||:::|.
Zfish   183 -----------------------------------------FSISDGELQDVGVG--LYPSMSLL 204

  Fly   474 NHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENYGPMY--TQDERS--------ERQARL---- 524
            ||.|.|..:..|.|..:.:.:||.|.:...:..:|..:.  ::|.||        |.||.|
Zfish   205 NHDCQPNCIMMFEGKRLTLRAVRVIRSAEELTISYTDILAPSKDRRSQHWDELLKESQALLHRHS 269

  Fly   525 -----KDLYW---FECSCDACIDNWPKFDD 546
                 :::|.   .:.:.||||    ..||
Zfish   270 DVVPDRNIYMLRLLDLAMDACI----SLDD 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	12/38 (32%)
smyd3	NP_001032477.1	zf-MYND	49..87	CDD:280009	12/38 (32%)
		SET	<201..239	CDD:279228	10/37 (27%)
		TPR_12	276..351	CDD:290160	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9821
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810