DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and smyd5

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001004614.2	Gene:	smyd5 / 447875	ZFINID:	ZDB-GENE-040912-39	Length:	415	Species:	Danio rerio

Alignment Length:	380	Identity:	86/380 - (22%)
Similarity:	134/380 - (35%)	Gaps:	100/380 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 NRQEGRFARASADVKPGEELLVERPFVS------VLLEKFAKTHC-------------------- 284
            |..:|:...|....|.|:.:.:|||.||      .|.:..|..:|
Zfish    28 NNVKGKGLFAKKPFKKGDTIFIERPLVSSQFLWNALYKYRACEYCLRALETAEENARRLSGLPAL 92

  Fly   285 -----ENCFMRTVVPVACPRCADVLYCSEQCREEASKKYHKYEC------------GIVPIIWRS 332
                 |.|.:|.....|||:| .|:|||.:||:.|..:|||..|            ..:...|||
Zfish    93 ILPHPELCKVRPDRHQACPQC-QVMYCSSECRQAAMDQYHKILCLGPSNDDPDHPVNKLQDAWRS 156

  Fly   333 GASINNHIALRIIASKPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLER---HQ--GERQP 392
            ........::.|:|        |:..||.:....|:...|..:...|.|..|.   |:  ||:
Zfish   157 VHFPPETSSVMILA--------KMVATIKQTQDKERWQRLFTNFCSRTANEEEEIVHKLLGEK-- 211

  Fly   393 SNFFQHV--LMARFLTNCL---RAGGYFGSEPKPDEVSIICSLV---------------LRSLQF 437
               ||..  |:....|..|   |...:|    .|:....:.|||               :.:...
Zfish   212 ---FQGQLGLLRNLFTTALYEDRLSQWF----TPEGFRSLFSLVGTNGQGIGTSSLSQWVHACDA 269

  Fly   438 IQFNTHEVAELHKF-----SSSGREKSIFI---GGAIYPTLALFNHSCDPGVVRYF--RGTTIHI 492
            ::....:..:|..|     ....:|...|:   |..::...:..||||.|.....|  ....:|:
Zfish   270 LELPRQQREQLDAFIDQLYKDIDKETGDFLNCEGSGLFLLQSSCNHSCVPNAEASFPENNFLLHL 334

  Fly   493 NSVRPIEAGLPINENYGPMYTQD-ERSERQARLKDLYWFECSCDACIDNWPKFDD 546
            .::..|..|..|..:|.....:| .|..|...|::.|.|.|||..|:.   :.||
Zfish   335 TALGDIGPGEEICISYLDCCQRDRSRHSRHKILRENYLFICSCQKCLS---QMDD 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	18/63 (29%)
smyd5	NP_001004614.2	zf-MYND	100..135	CDD:280009	16/35 (46%)
smyd5	NP_001004614.2	SET	<293..350	CDD:214614	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810