DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd4-3 and Smyd3

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_524768.2	Gene:	Smyd3 / 44554	FlyBaseID:	FBgn0011566	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	102/462 - (22%)
Similarity:	171/462 - (37%)	Gaps:	138/462 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 IDSNRQEGRFARASA-------------DVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVP 294
            :.|:|.....|.|||             .:|.|:.:|.|:||..||..::....|:||...|.|
  Fly     6 VGSSRSATTSATASACSSKSKNLKNPAPQIKRGQRILTEKPFAFVLKSQYRLERCDNCLEATKV- 69

  Fly   295 VACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPT 359
            :.|..|..|.||...|:.:|..: ||:||.                            |||   .
  Fly    70 LKCSNCRYVSYCHRSCQMQAWGQ-HKHECP----------------------------FLK---K 102

  Fly   360 IDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQH------VLMARFLTNCLRAGGYFGSE 418
            :...:.|:....|    .|.:.:|| |.|:.....:.:|      .||:.:            :|
  Fly   103 VHPRVVPDAARML----CRLILRLE-HGGDLIRGYYTEHGSRKFRDLMSHY------------AE 150

  Fly   419 PKPDEV---------SIICSLVLRSLQFIQFNTHEVAELHKFSSSG----REKSIFIGGAIYPTL 470
            .|.|.:         :::..::..|...:...|..::...:..::|    ..:...|..|||..:
  Fly   151 IKNDPMRLEHLDSLHAVLTDMMAESPSTVPNKTELMSIYGRLITNGFNILDAEMNSIATAIYLGV 215

  Fly   471 ALFNHSCDPGVVRYFRGTTIHINSVRPIEA--GLPINENYGPMYTQDERSERQARLKDLYWFECS 533
            ::.:|||.|..|..|.|..:|::::..:|.  ...|..:|..:....|  :|:..||:.|:|.|.
  Fly   216 SITDHSCQPNAVATFEGNELHVHAIEDMECLDWSKIFISYIDLLNTPE--QRRLDLKEHYYFLCV 278

  Fly   534 CDACIDNWPKFDDLPRDVIRFRCDAPN-NCSAVIEVPPSCNDFMVKCVTCG-----EITNILKGL 592
            |..|.|....     ::::...|  || ||.|.|.|..:      .|..|.     ::.|..
  Fly   279 CSKCTDAKES-----KEMLAALC--PNRNCGAGISVDRN------NCPRCDAGISPKLRNAF--- 327

  Fly   593 KVMQDTEMMTRTAKRLYETGEYPKALAKFVDLIRIMYE----VLAPPFPDFCESQQHLKDCFLNL 653
                 .|.||.|...|    |..|.:| ::|:.::..:    |..|                ||:
  Fly   328 -----NEAMTLTRHNL----ENMKDVA-YLDVCKVCLDKQTGVFHP----------------LNV 366

  Fly   654 GNVYTLD 660
            ..|.|||
  Fly   367 WYVKTLD 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	14/38 (37%)
Smyd3	NP_524768.2	zf-MYND	60..97	CDD:280009	14/38 (37%)
Smyd3	NP_524768.2	TPR_12	377..440	CDD:290160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X437
	3	2.810