DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and SmydA-1

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_610944.1	Gene:	SmydA-1 / 36581	FlyBaseID:	FBgn0033917	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	442	Identity:	93/442 - (21%)
Similarity:	168/442 - (38%)	Gaps:	105/442 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 KQQKQ--KIALDQAKPVKLENEFVSPLVRIDSNRQEGRFARASADVKPGEELLVERPFVSVLLEK 278
            :.|||  |:......|.|:.:           |.|.||...|:..:||.|.:|.|.|.|....:.
  Fly    27 QHQKQDWKVHKPSCHPFKIAH-----------NEQLGRHLVATRTIKPYEIVLKEAPLVRGPAQI 80

  Fly   279 FAKTHCENCF--MRTVVPVACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIA 341
            .|.. |..|.  :.....:.|.:|...| |..:|:   |...||.|||:..   ..|..:|   .
  Fly    81 SAPV-CLGCLNGIEAEDHIECEQCGWPL-CGPECK---SLDEHKAECGLTK---DRGQKVN---V 134

  Fly   342 LRIIASKPLDYFLK-LKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQH--VLMAR 403
            .......||...|. ::..:..|.:.|:.        .:...||..:..|:.||.::.  |.:.:
  Fly   135 QEFGGPHPLYTCLSTVRCLLIGETSTEKA--------SKFQDLESLESTRRGSNQWKADLVSIGQ 191

  Fly   404 FLTNCLRAGGYFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAEL---HKFSSSGREKSIFIGGA 465
            |:..      :|.::...:|.      :::::..:|.|.|||...   |.              |
  Fly   192 FIPK------FFKTQKFTEEE------IMKAVGALQINGHEVPTTDPSHV--------------A 230

  Fly   466 IYPTLALFNHSCDPGVVRYF--RGTTIHINSVRPIEAGLPINENYG-PMYTQDERSERQARLKDL 527
            ::.|.:...:||.|.:.:.|  .|..| :.:.|.|:....::..|. .|:   ..::||..|...
  Fly   231 VFYTASFTENSCLPNLAKSFNKNGHCI-LWAPREIKKNAHLSICYSDAMW---GTADRQRHLMQT 291

  Fly   528 YWFECSCDACIDNWPKFDDLPRDVIRFRCDAPNNCSAVIEVPPSCNDF--MVKCVTCGE------ 584
            ..|:|:|:.|:|    ..:|..:....:|: ...|..:: :|...:::  ..:|..|.:
  Fly   292 KLFKCACERCVD----VTELDTNYSAIKCE-DRQCGGLM-LPTKADEWNGSWRCRECHKQVQKHY 350

  Fly   585 ITNILKGLKVMQDTEMMTRTAKRLYETG-EYPKALAKFVDLIRIMYEVLAPP 635
            :..||:  :..:|.:.|.:.|    |.| :|.|           .||...||
  Fly   351 VERILE--RAGKDIQSMEKIA----ENGLKYLK-----------HYEKWLPP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	10/40 (25%)
SmydA-1	NP_610944.1	zf-MYND	4..40	CDD:280009	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810