DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd4-3 and SmydA-5

DIOPT Version :9

Sequence 1:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	86/455 - (18%)
Similarity:	156/455 - (34%)	Gaps:	125/455 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 AMTMIKMLQN-DPRTAKQEAKQQKQKIALDQAKPVKLENEFVSPLVRIDSNRQEGRFARASADVK 260
            |.|..||::. |....||...|.|::     .:|...|.:           .:.||:.:.:.::.
  Fly    17 ACTRCKMVRYCDREHQKQHWPQHKRR-----CRPFSEEQD-----------AELGRYLKVTQNIA 65

  Fly   261 PGEELLVERP-------FVSVLLEKFAKTHCENCFMRTVVPV-----ACPRCADVLYCSEQCREE 313
            .|:.:.:|.|       ::|...::.:...|..|:    .|.     .|.||...: ||..|:.|
  Fly    66 AGQIVFIEEPLVVGPKWYLSDADKEASNVPCVGCY----TPCRLGKHQCRRCRWPV-CSAGCKHE 125

  Fly   314 ASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYF-----LKLKPTIDEELTPEQLISLP 373
            :      .||.::        |:.:....|..|....|||     |.||..:.:..:|.:..:|
  Fly   126 S------MECSVL--------SLGSGSPTRADARSLNDYFRGDALLVLKCLLLQRQSPTKWSAL- 175

  Fly   374 KDDFRRVAQLERHQGERQPSNFFQHV-------LMARFLTNCLRAGGYFGSEPKPDEVSIICSLV 431
                   .:::.|:.||:.::.::..       |..|||....:......::..|:.:..:|.::
  Fly   176 -------LEMQSHEEERKGTDLYEEAEKRVVTYLQKRFLCRLKQTNPNLLTDCGPEMLHRLCGII 233

  Fly   432 LRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVR 496
            ..:...|:.            .||.|.|     .::....:..|:|.|.....|...|..:
  Fly   234 ETNFMVIEL------------PSGVELS-----GLFRQACMMEHACQPNCDFQFDNKTQQV---- 277

  Fly   497 PIEAGLPINEN-----------YGPMYTQDERSERQARLKDLYWFECSCDACIDNWPKFDDLPRD 550
            .:.||..:.:.           :|...       ||..|:....|.|.|..|:|        |.:
  Fly   278 AVRAGCDLRKGDHLRITYTNILWGTQL-------RQHHLRLTKHFSCRCSRCLD--------PTE 327

  Fly   551 ----VIRFRC--DAPNNCSAV-IEVPPSCNDFMVKCVTCGEITNILKGLKVMQDTEMMTRTAKRL 608
                :....|  |....|... :.|.|...:...||.||   ..|:.|..|.:....||...:.|
  Fly   328 YGTYISALTCLGDVNQTCGGTHLPVDPLDENTQWKCDTC---PMIVDGAYVAELQSHMTEQVEGL 389

Fly 609 608
Fly 390 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	10/43 (23%)
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009	9/30 (30%)
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	19/130 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810